Evidence map›Paper›PMID 32495496›Full record

ArticleLiver international : official journal of the International Association for the Study of the Liver2020

Abnormal liver tests in patients hospitalized with Coronavirus disease 2019: Should we worry?

Magdalena Meszaros, Lucy Meunier, David Morquin, Kada Klouche, Pierre Fesler, Emilie Malezieux, Alain Makinson, Vincent Le Moing, Jacques Reynes, Georges-Philippe Pageaux

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Liver international : official journal of the International Association for the Study of the Liver, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 4 pooled it
0.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
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  13. Mild versus Severe Liver Injury in SARS-CoV-2 Infection.Digestive diseases (Basel, Switzerland) · 2021
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  15. Abnormal liver tests in patients hospitalized with Coronavirus disease 2019: Should we worry?Liver international : official journal of the International Association for the Study of the Liver · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Magdalena MeszarosDepartment of Hepatology, Gastroenterology and Liver Transplantation, Montpellier University Hospital, University of Montpellier, Montpellier, France.ORCID 0000-0002-5569-7285
Lucy MeunierDepartment of Hepatology, Gastroenterology and Liver Transplantation, Montpellier University Hospital, University of Montpellier, Montpellier, France.
David MorquinDepartment of Infectious Diseases, Montpellier University Hospital, University of Montpellier, Montpellier, France.
Kada KloucheDepartment of Intensive Care Lapeyronie, Montpellier University Hospital, University of Montpellier, Montpellier, France.
Pierre FeslerDepartment of Internal Medicine Lapeyronie, Montpellier University Hospital, University of Montpellier, Montpellier, France.
Emilie MalezieuxDepartment of Hepatology, Gastroenterology and Liver Transplantation, Montpellier University Hospital, University of Montpellier, Montpellier, France.
Alain MakinsonDepartment of Infectious Diseases, Montpellier University Hospital, University of Montpellier, Montpellier, France.
Vincent Le MoingDepartment of Infectious Diseases, Montpellier University Hospital, University of Montpellier, Montpellier, France.
Jacques ReynesDepartment of Infectious Diseases, Montpellier University Hospital, University of Montpellier, Montpellier, France.
Georges-Philippe PageauxDepartment of Hepatology, Gastroenterology and Liver Transplantation, Montpellier University Hospital, University of Montpellier, Montpellier, France.
Université de Montpellier · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While several studies from China have reported COVID-19-related liver injury, there are currently no data on liver dysfunction in hospitalized COVID-19 patients in Europe. The aim of this study was to describe the prevalence and predictive value of abnormal liver function in patients hospitalized with COVID-19. This was a retrospective cohort study of confirmed COVID-19 patients hospitalized in two referral hospitals in France. Clinical, biological and radiological data were collected and analysed. In all, 234 patients confirmed to have COVID-19 by RT-PCR were included. Liver function was abnormal in 66.6% of patients on admission. In multivariate logistic regression, abnormal liver test on admission were associated with in-hospital aggravation (OR = 4.1, 95% CI 1.5-10.8; P = .004) and mortality (OR 3.3; 95% CI = 1.04-10.5; P = .04). This study of liver tests in a European COVID-19 population confirms a high prevalence of abnormal liver tests on admission that are predictive of severe disease course and higher in-hospital mortality.

Indexed as

BetacoronavirusAgedAged, 80 and overCoronavirus InfectionsCOVID-19FemaleHospitalizationHumansLiverLiver Function TestsLogistic ModelsMaleMiddle AgedPandemicsPneumonia, ViralRetrospective Studiesabnormal liver testsCoronavirus disease 2019in-hospital aggravationin-hospital mortalityprognosisSARS-CoV-2

Identifiers

PMID32495496
PMCPMC7300742
OpenAlexW3028945897

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.