ArticleJournal of cardiovascular translational research2020
Correlation Between Wall Shear Stress and Acute Degradation of the Endothelial Glycocalyx During Cardiopulmonary Bypass.
Article in Journal of cardiovascular translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Exploring Glycocalyx shedding markers: A comparative analysis of plasma markers among premenopausal and postmenopausal women.Physiological reports · 2026Article
- Article
- Observational
- Predictive role of glycocalyx components and MMP-9 in cardiopulmonary bypass patients for ICU stay.Heliyon · 2024Article
- Delirium after Cardiac Surgery-A Narrative Review.Brain sciences · 2023Review
- Wall Shear Stress Alteration: a Local Risk Factor of Atherosclerosis.Current atherosclerosis reports · 2022Review
- Endothelial glycocalyx in hepatopulmonary syndrome: An indispensable player mediating vascular changes.Frontiers in immunology · 2022Review
- Arterial Pulsatility Augments Microcirculatory Perfusion and Maintains the Endothelial Integrity during Extracorporeal Membrane Oxygenation via hsa_circ_0007367 Upregulation in a Canine Model with Cardiac Arrest.Oxidative medicine and cellular longevity · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wall shear stress (WSS) plays a key role in maintaining glycocalyx function, gene expression, and structure. Experimental studies have discussed the relationship between the shedding of the endothelial glycocalyx (EG) and WSS. However, rare literature about how WSS affects the EG during cardiopulmonary bypass (CPB) was mentioned. This study aimed to investigate the correlation between the WSS of carotid arteries and shedding of the EG during CPB in humans. The WSS level was calculated in accordance with an equation. The plasma concentrations of heparan sulfate, syndecan-1, and nitric oxide were measured to reflect shedding of the EG at six time points. A negative correlation was observed between the peak wall shear stress (PWSS) and syndecan-1 (R = - 0.5, p < 0.01) and heparan sulfate (R = - 0.461, p < 0.01) during CPB. The WSS is closely associated with the components of glycocalyx shedding during CPB. The WSS produced by non-pulsatile flow during CPB may contribute to the degradation of EG.
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Registered trials
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