Evidence map›Paper›PMID 32495256›Full record

ArticleDigestive diseases and sciences2021

Patient-Reported Outcomes and Blood-Based Parameters Identify Response to Treatment in Eosinophilic Esophagitis.

Christine Lingblom, Sofie Albinsson, Leif Johansson, Helen Larsson, Christine Wennerås

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Digestive diseases and sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Shifting the scope: Moving toward less invasive diagnosis and monitoring of eosinophilic esophagitis.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026
    Review
  4. Eosinophilic gastrointestinal diseases.Nature reviews. Disease primers · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Validation of the Swedish Watson Dysphagia Scale for adult patients with eosinophilic esophagitis.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2022
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Christine LingblomDepartment of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Guldhedsgatan 10A, 413 46, Göteborg, Sweden.
Sofie AlbinssonDepartment of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Guldhedsgatan 10A, 413 46, Göteborg, Sweden. sofie.albinsson@gu.se.ORCID 0000-0003-2038-4286
Leif JohanssonDepartment of ENT, Head and Neck Surgery, Skövde County Hospital, Skaraborgs Sjukhus, Lövängsvägen, 541 42, Skövde, Sweden.
Helen LarssonDepartment of ENT, Head and Neck Surgery, NU Hospital Group, Lärketorpsvägen, 461 73, Trollhättan, Sweden.
Christine WenneråsDepartment of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Guldhedsgatan 10A, 413 46, Göteborg, Sweden.

Funding

Göteborgs UniversitetGöteborgs Universitet -Health & Medical Care Committee of the Regional Executive Board of Region Västra Götaland 94920IngaBritt och Arne Lundbergs ForskningsstiftelseIngaBritt och Arne Lundbergs Forskningsstiftelse -The Cancer and Allergy Foundation 18-228The Swedish state under the agreement between the Swedish government and the county councils, the ALF agreement 71580
6 · The paper itself

Abstract

backgroundNoninvasive methods to assess treatment response in eosinophilic esophagitis are needed.

aimsOur aim was to determine whether a blood-based biomarker panel centered on immune parameters could identify histologic response to treatment in eosinophilic esophagitis patients.

methodsA pilot study involving adult patients with active eosinophilic esophagitis recruited at two Ear, Nose, Throat clinics in Sweden was designed. The patients (n = 20) donated blood and esophageal biopsies and filled in three questionnaires before and after a 2-month course of topical corticosteroids. Blood samples were analyzed for absolute levels of granulocytes and T cells and the fractions of eosinophils expressing 10 different surface markers by flow cytometry. All data were analyzed by multivariate methods of pattern recognition.

resultsMultivariate modeling revealed that a combination of 13 immune parameters and 10 patient-reported outcome scores were required to create a model capable of separating responders (n = 15) from non-responders (n = 5). Questions regarding symptoms of esophageal dysfunction and capacity to eat certain foods from two of the questionnaires were discriminatory in the multivariate model, as were absolute counts of T cells, eosinophils, and eosinophil expression of activation markers and cell adhesion molecules.

conclusionsA combination of blood-based immune parameters and directed questions may prove helpful to monitor response to treatment, perhaps reducing the need for repeat endoscopies in eosinophilic esophagitis patients in the future.

Indexed as

Flow CytometryPatient Reported Outcome MeasuresAdministration, TopicalAdolescentAdrenal Cortex HormonesAdultAgedBiomarkersCell Adhesion MoleculesEosinophilic EsophagitisEosinophilsFemaleHumansMaleMiddle AgedPilot ProjectsAdrenal Cortex HormonesBiomarkersCell Adhesion MoleculesBiomarkerCD16Eosinophilic esophagitisEosinophilsPatient-reported outcomeT cells

Identifiers

PMID32495256
PMCPMC8053156

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.