Evidence map›Paper›PMID 32495225›Full record

ArticleClinical oral investigations2021

Bone microRNA-21 as surgical stress parameter is associated with third molar postoperative discomfort.

Milan Vucetic, Jelena Roganovic, Martin Freilich, David Shafer, Marija Milic, Ljiljana DJukic, Nina Petrovic, Evgenija Markovic, Aleksa Markovic, Bozidar Brkovic

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Article in Clinical oral investigations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
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  6. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Milan VuceticDepartment of Oral Surgery, School of Dental Medicine, University of Belgrade, Dr Subotica 4, Belgrade, 11000, Serbia.
Jelena RoganovicDepartment of Pharmacology in Dentistry, School of Dental Medicine, University of Belgrade, Belgrade, Serbia.
Martin FreilichDepartment of Reconstructive Sciences, School of Dental Medicine, University of Connecticut, Farmington, CT, USA.
David ShaferDepartment of Craniofacial Sciences, Division of Oral & Maxillofacial Surgery, School of Dental Medicine, University of Connecticut, Farmington, CT, USA.
Marija MilicDepartment of Oral Surgery, School of Dental Medicine, University of Belgrade, Dr Subotica 4, Belgrade, 11000, Serbia.
Ljiljana DJukicDepartment of Pharmacology in Dentistry, School of Dental Medicine, University of Belgrade, Belgrade, Serbia.
Nina PetrovicDepartment of Radiobiology and Molecular Genetics, Institute of Nuclear Sciences Vinca, University of Belgrade, Belgrade, Serbia.
Evgenija MarkovicDepartment of Orthodontics, School of Dental Medicine, University of Belgrade, Belgrade, Serbia.
Aleksa MarkovicDepartment of Oral Surgery, School of Dental Medicine, University of Belgrade, Dr Subotica 4, Belgrade, 11000, Serbia.
Bozidar BrkovicDepartment of Oral Surgery, School of Dental Medicine, University of Belgrade, Dr Subotica 4, Belgrade, 11000, Serbia. brkovic73@yahoo.com.ORCID http://orcid.org/0000-0002-4501-5455
University of Belgrade · RSUniversity of Connecticut · US

Funding

Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja 175021
6 · The paper itself

Abstract

objectiveTo evaluate an association between bone levels of inflammation/oxidative stress mediators and postoperative discomfort after third molar conventional or piezosurgery. MATERIAL AND

methodsTwenty-six subjects with bilaterally impacted mandibular third molars, who underwent either piezo or conventional surgery, were included in a split-mouth design study. MicroRNA-21 (miR-21) expression, interleukin-1 beta (IL-1β), and vascular endothelial growth factor (VEGF) proteins, as well as superoxide dismutase (SOD) activity in alveolar bone, were evaluated. Pain intensity, the first pain appearance, analgesic first use and total dose taken, trismus, and swelling were clinically recorded.

resultsMiR-21 expression was higher while VEGF protein was lower in piezosurgery vs. conventional groups. The differences in IL-1β protein and SOD activity were not significant between groups. The pain intensity on the first day was significantly decreased in piezosurgery group. The first pain appearance and the first analgesic taken were reported sooner in conventional vs. piezosurgical group. Significantly pronounced trismus on the third day following conventional surgery was found. In conventional group, significantly increased trismus was observed on the third compared to the first postoperative day. MiR-21 showed significant correlation with the first pain appearance.

conclusionDelayed onset of less pronounced postoperative pain after piezosurgical vs. conventional extraction of impacted lower third molar was significantly associated with expression of bone miR-21. CLINICAL RELEVANCE: Alveolar bone miR-21 may reflect surgical stress and is associated with third molar postoperative pain onset.

Indexed as

MicroRNAsTooth, ImpactedEdemaHumansMandibleMolar, ThirdPostoperative PainTooth ExtractionTrismusVascular Endothelial Growth Factor AMicroRNAsMIRN21 microRNA, humanVascular Endothelial Growth Factor AIL-1βLower third molarmiR-21PiezoSODVEGF

Identifiers

PMID32495225
OpenAlexW3032508698

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.