ArticleHernia : the journal of hernias and abdominal wall surgery2020
Comparison of ıncisional hernia models ın rats: an experimental study.
Article in Hernia : the journal of hernias and abdominal wall surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 6 citations in OpenAlex.
- Validation of a rat parastomal hernia model for evaluating mesh biocompatibility and repair outcomes.Hernia : the journal of hernias and abdominal wall surgery · 2026Article
- Self-gripping versus polypropylene mesh for incisional hernia repair in a rat model.Surgical endoscopy · 2025Article
- Establishment and evaluation of rat models of parastomal hernia.Hernia : the journal of hernias and abdominal wall surgery · 2024Article
- Construction and properties of the silk fibroin and polypropylene composite biological mesh for abdominal incisional hernia repair.Frontiers in bioengineering and biotechnology · 2022Article
- Effects of 5-fluorouracil released from different prosthetic meshes on post-operative adhesion formation in rats.Northern clinics of Istanbul · 2022Article
- Analysis of tissue inflammatory response, fibroplasia, and foreign body reaction between the polyglactin suture of abdominal aponeurosis in rats and the intraperitoneal implant of polypropylene, polypropylene/polyglecaprone and polyester/porcine collagen meshes.Acta cirurgica brasileira · 2021Article
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Authors and funding
8 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIncisional hernia repair is a frequently performed operation worldwide. In this experimental study, our aim is to present the incisional hernia model after creating midline laparotomy and several type of defects on abdominal wall of the rats. Thereby, the method determined here may be used in future experimental incisional hernia repair studies.
methodsAfter approval, 32 male rats were randomly seperated into 4 groups of 8 animals each, and were operated to form an incisional hernia; Sham group, 5 cm incision group, 5 cm incision plus capitonnage group, and 5 cm incision plus 2 × 4 cm muscle excision group, respectively. On the 28th postoperative day after killing, the abdominal anterior wall of rats were removed for histopathological and biomechanic examination.
resultsThe incisional hernia size was found to be statistically different in at least one group (p = 0.001). The incisional hernia size in Group 4 was found to be significantly higher than Group 2 (p = 0.001). When the tension and elongation values were examined, there was a difference in at least one group (p < 0.001 and p = 0.029, respectively). Histopathological examination shows that the degree of inflammation and fibrosis varies significantly (p = 0.001 and p = 0.002, respectively).
conclusionThis study has lead us to believe that the rat model created by applying muscle excision from the midline of the abdomen is the ideal incisional hernia model that can be used in future experimental incisional hernia studies.
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