Evidence map›Paper›PMID 32494978›Full record

SynthesisMolecular biology reports2020

Polymorphisms in GSTT1 and GSTM1 genes as possible risk factors for susceptibility to breast cancer development and their influence in chemotherapy response: a systematic review.

Letícia Madureira Pacholak, Marla Karine Amarante, Roberta Losi Guembarovski, Maria Angélica Ehara Watanabe, Carolina Panis

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Molecular biology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Predicted Proteome Association Studies of Breast, Prostate, Ovarian, and Endometrial Cancers Implicate Plasma Protein Regulation in Cancer Susceptibility.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023
    Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Letícia Madureira PacholakLaboratório Biologia de Tumores and Programa de Pós-Graduação em Ciências Aplicadas à Saúde, Universidade Estadual do Oeste do Paraná, Rodovia Vitório Traiano, Km2 - Água Branca, Francisco Beltrão, Paraná, Brazil.
Marla Karine AmaranteLaboratório de Estudos e Aplicações de Polimorfismo de DNA, Universidade Estadual de Londrina, Londrina, PR, Brazil.
Roberta Losi GuembarovskiLaboratório de Estudos e Aplicações de Polimorfismo de DNA, Universidade Estadual de Londrina, Londrina, PR, Brazil.
Maria Angélica Ehara WatanabeLaboratório de Estudos e Aplicações de Polimorfismo de DNA, Universidade Estadual de Londrina, Londrina, PR, Brazil.
Carolina PanisLaboratório Biologia de Tumores and Programa de Pós-Graduação em Ciências Aplicadas à Saúde, Universidade Estadual do Oeste do Paraná, Rodovia Vitório Traiano, Km2 - Água Branca, Francisco Beltrão, Paraná, Brazil. carolpanis@hotmail.com.ORCID http://orcid.org/0000-0002-0104-4369

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior -Fundação Araucária -
6 · The paper itself

Abstract

Breast cancer (BC) is a heterogeneous and multifactorial disease. The system formed by glutathione-S-transferases (GSTs) acts to protect the organism against the oxidative stress generated by xenobiotics and their active products. Glutathione transferase mu 1 (GSTM1) and glutathione transferase theta 1 (GSTT1) present null polymorphic variants by complete deletion. The absence of these enzymes may influence the susceptibility to several diseases such as BC. This study aimed to systematically review and investigate the existence of a possible correlation between the presence/absence of these genetic variants and the development of BC and their influence in chemotherapy response. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol was used, and the searches were performed in the portal of the Virtual Health Library (VHL) and the PubMed, resulting in 21 articles. It is clear that most studies revealed a risk association between the deletion of GSTM1 and/or GSTT1 and the development and/or prognosis of BC.Moreover, it should be noted that these results of risk association were found in large part in the populations of the Americas and Europe, followed by Asians. Regarding the response to treatment, protective associations were found in the presence of GSTM1 deletion. However, due to the inconclusive results of many studies, further analysis in this area is required.

Indexed as

Biomarkers, PharmacologicalBreast NeoplasmsCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenotypeGlutathione S-Transferase piGlutathione TransferaseHumansPolymorphism, Single NucleotidePrognosisRisk FactorsBiomarkers, PharmacologicalGlutathione S-Transferase piglutathione S-transferase T1Glutathione TransferaseBreast cancerGlutathionePolymorphismXenobiotics

Identifiers

PMID32494978

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.