Evidence map›Paper›PMID 32494802›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2020

Bipartite Functional Fractionation within the Default Network Supports Disparate Forms of Internally Oriented Cognition.

Rocco Chiou, Gina F Humphreys, Matthew A Lambon Ralph

Abstract read
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Resolving the Abstract-Concrete Paradox in the Angular Gyrus: A Multimethod Investigation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  4. Sender-receiver subdivisions of the default mode network in perceptual and memory-guided cognition.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Narrative "twist" shifts within-individual neural representations of dissociable story features.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Article
  8. The Dimensionality of Neural Coding for Cognitive Control Is Gradually Transformed within the Lateral Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Creativity in verbal associations is linked to semantic control.Cerebral cortex (New York, N.Y. : 1991) · 2023
    Article
  13. Article
  14. Article
  15. Task-specific network interactions across key cognitive domains.Cerebral cortex (New York, N.Y. : 1991) · 2022
    Article
  16. Article
  17. Article
  18. Spatially Adjacent Regions in Posterior Cingulate Cortex Represent Familiar Faces at Different Levels of Complexity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Rocco ChiouMRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge UK.
Gina F HumphreysMRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge UK.
Matthew A Lambon RalphMRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge UK.

Funding

Medical Research Council MC_UU_00005/18Medical Research Council MR/R023883/1Wellcome Trust 201381/Z/16/Z
6 · The paper itself

Abstract

Our understanding about the functionality of the brain's default network (DN) has significantly evolved over the past decade. Whereas traditional views define this network based on its suspension/disengagement during task-oriented behavior, contemporary accounts have characterized various situations wherein the DN actively contributes to task performance. However, it is unclear how different task-contexts drive componential regions of the DN to coalesce into a unitary network and fractionate into different subnetworks. Here we report a compendium of evidence that provides answers to these questions. Across multiple analyses, we found a striking dyadic structure within the DN in terms of the profiles of task-triggered fMRI response and effective connectivity, significantly extending beyond previous inferences based on meta-analysis and resting-state activities. In this dichotomy, one subset of DN regions prefers mental activities "interfacing with" perceptible events, while the other subset prefers activities "detached from" perceptible events. While both show a common "aversion" to sensory-motoric activities, their differential preferences manifest a subdivision that sheds light upon the taxonomy of the brain's memory systems. This dichotomy is consistent with proposals of a macroscale gradational structure spanning across the cerebrum. This gradient increases its representational complexity, from primitive sensory-motoric processing, through lexical-semantic representations, to elaborated self-generated thoughts.

Indexed as

AdultBrainBrain MappingCognitionDefault Mode NetworkFemaleHumansMagnetic Resonance ImagingMaleMemoryPsychophysicsSemanticsYoung Adultconnectivitydefault-mode networkmemorysemantic cognitiontopography

Identifiers

PMID32494802
PMCPMC7472201

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.