ArticleScience advances2020
Multimodal mapping of neural activity and cerebral blood flow reveals long-lasting neurovascular dissociations after small-scale strokes.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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Who cites it
48 citing papers in PubMed, 75 citations in OpenAlex.
- Minimally invasive bioelectronic implants.Nature materials · 2026Review
- Signatures of Covert Neuron Loss in the Local Field Potential of Motor Cortex.Journal of the American Heart Association · 2026Article
- Simultaneous In Vivo Electrophysiology, Two-Photon Imaging, and Optogenetics for Probing Neurovascular Coupling.Methods and protocols · 2026Article
- A cortex-wide multimodal microscope for simultaneous CaNature communications · 2025Article
- Advancing intraoperative cerebral blood flow monitoring: integrating imaging photoplethysmography and laser speckle contrast imaging in neurosurgery.Frontiers of optoelectronics · 2025Article
- Materials and device strategies to enhance spatiotemporal resolution in bioelectronics.Nature reviews. Materials · 2025Article
- Longitudinal, Multimodal Tracking Reveals Lasting Neurovascular Impact of Individual Microinfarcts.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Neuromodulation of Cerebral Blood Flow: A Physiological Mechanism and Methodological Review of Neurovascular Coupling.Bioengineering (Basel, Switzerland) · 2025Review
- A molecular brain atlas reveals cellular shifts during the repair phase of stroke.Journal of neuroinflammation · 2025Article
- Early changes in spatiotemporal dynamics of remapped circuits and global networks predict functional recovery after stroke in mice.Neurophotonics · 2025Article
- Review
- Phasic perfusion dynamics among migraine subtypes: a multimodel arterial spin labeling investigation.The journal of headache and pain · 2024Article
- Achieving optical transparency in live animals with absorbing molecules.Science (New York, N.Y.) · 2024Article
- Social deficits mirror delayed cerebrovascular dysfunction after traumatic brain injury.Acta neuropathologica communications · 2024Article
- Ultraflexible electrodes for recording neural activity in the mouse spinal cord during motor behavior.Cell reports · 2024Article
- Micro-ultrasound based characterization of cerebrovasculature following focal ischemic stroke and upon short-term rehabilitation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Article
- Serum Homer1 is a Novel Biomarker for Predicting the Clinical Outcomes of Acute Ischemic Stroke Patients.Journal of inflammation research · 2024Article
- Rethinking Remapping: Circuit Mechanisms of Recovery after Stroke.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- Subventricular zone cytogenesis provides trophic support for neural repair in a mouse model of stroke.Nature communications · 2023Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Neurovascular coupling, the close spatial and temporal relationship between neural activity and hemodynamics, is disrupted in pathological brain states. To understand the altered neurovascular relationship in brain disorders, longitudinal, simultaneous mapping of neural activity and hemodynamics is critical yet challenging to achieve. Here, we use a multimodal neural platform in a mouse model of stroke and realize long-term, spatially resolved tracking of intracortical neural activity and cerebral blood flow in the same brain regions. We observe a pronounced neurovascular dissociation that occurs immediately after small-scale strokes, becomes the most severe a few days after, lasts into chronic periods, and varies with the level of ischemia. Neuronal deficits extend spatiotemporally, whereas restoration of cerebral blood flow occurs sooner and reaches a higher relative value. Our findings reveal the neurovascular impact of ministrokes and inform the limitation of neuroimaging techniques that infer neural activity from hemodynamic responses.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.