ArticleScience advances2020
Particle-based artificial three-dimensional stem cell spheroids for revascularization of ischemic diseases.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Engineered extracellular vesicles for ischemic heart diseases: modification methods, targeted delivery strategies, and multi-modal therapies - A systematic review.Frontiers in cardiovascular medicine · 2026Pooled it
- Photo-triggered NO combined with photobiomodulation promotes endothelial repair after balloon angioplasty.Materials today. Bio · 2026Article
- Microneedle technology integrated with diverse therapeutic modalities for hair regrowth in alopecia.Acta pharmaceutica Sinica. B · 2026Review
- Lipoic Acid-Intervened Decellularized Stem Cell Spheroid-Based Injectable Granular Gel for Diabetic Tissue Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Granzyme B-mimetic nanozyme for nanovesicle targeted anticancer applications.Nature communications · 2026Article
- Optimizing adipose-derived stem cell therapy for diabetic foot ulcers.World journal of diabetes · 2025Article
- Dynamic three-dimensional culture enhances tunneling nanotubes-mediated mitochondrial transfer in mesenchymal stromal cells to accelerate wound healing.Journal of nanobiotechnology · 2025Article
- Minimally invasive snakebite inspired microneedle delivery system for internal organs.Bioactive materials · 2025Article
- Analytical solution of a microrobot-blood vessel interaction model.Nonlinear dynamics · 2025Article
- Smart Microneedle Arrays Integrating Cell-Free Therapy and Nanocatalysis to Treat Liver Fibrosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Versatile Design of NO-Generating Proteolipid Nanovesicles for Alleviating Vascular Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Sulfated oligosaccharide activates endothelial Notch for inducing macrophage-associated arteriogenesis to treat ischemic diseases.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Neural tissue-engineered prevascularizationMaterials today. Bio · 2023Article
- Microstructured Polymeric Fabrics Modulating the Paracrine Activity of Adipose-Derived Stem Cells.International journal of molecular sciences · 2023Article
- M2 Macrophage-Derived sEV Regulate Pro-Inflammatory CCR2Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Red blood cell membrane-camouflaged poly(lactic-co-glycolic acid) microparticles as a potential controlled release drug delivery system for local stellate ganglion microinjection.Acta biomaterialia · 2023Article
- Light-controlled scaffold- and serum-free hard palatal-derived mesenchymal stem cell aggregates for bone regeneration.Bioengineering & translational medicine · 2023Article
- Bolstering the secretion and bioactivities of umbilical cord MSC-derived extracellular vesicles with 3D culture and priming in chemically defined media.Nano convergence · 2022Article
- Correct Identification of the Core-Shell Structure of Cell Membrane-Coated Polymeric Nanoparticles.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Engineering microparticles based on solidified stem cell secretome with an augmented pro-angiogenic factor portfolio for therapeutic angiogenesis.Bioactive materials · 2022Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Development of new approaches to biomimetically reconstruct vasculature networks remains challenging in regenerative medicine. We introduce a particle-based artificial stem cell spheroid (ASSP) technology that recapitulates paracrine functions of three-dimensional (3D) SSPs for vasculature regeneration. Specifically, we used a facile method to induce the aggregation of stem cells into 3D spheroids, which benefited from hypoxia microenvironment-driven and enhanced secretion of proangiogenic bioactive factors. Furthermore, we artificially reconstructed 3D spheroids (i.e., ASSP) by integration of SSP-secreted factors into micro-/nanoparticles with cell membrane-derived surface coatings. The easily controllable sizes of the ASSP particles provided superior revascularization effects on the ischemic tissues in hindlimb ischemia models through local administration of ASSP microparticles and in myocardial infarction models via the systemic delivery of ASSP nanoparticles. The strategy offers a promising therapeutic option for ischemic tissue regeneration and addresses issues faced by the bottlenecked development in the delivery of stem cell therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.