Evidence map›Paper›PMID 32494643›Full record

ArticleScience advances2020

N6-adenosine methylation of ribosomal RNA affects lipid oxidation and stress resistance.

Noa Liberman, Zach K O'Brown, Andrew Scott Earl, Konstantinos Boulias, Maxim V Gerashchenko, Simon Yuan Wang, Colette Fritsche, Paul-Enguerrand Fady, Anna Dong, Vadim N Gladyshev and 1 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. METTL5-mediated 18S rRNA mMolecular therapy : the journal of the American Society of Gene Therapy · 2023
    Article
  9. Article
  10. Ghost authors revealed: The structure and function of human NWiley interdisciplinary reviews. RNA · 2023
    Review
  11. Article
  12. Ribosome biogenesis and function in development and disease.Development (Cambridge, England) · 2023
    Review
  13. Article
  14. Biological roles of adenine methylation in RNA.Nature reviews. Genetics · 2023
    Review
  15. Article
  16. From correlation to causation: The new frontier of transgenerational epigenetic inheritance.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023
    Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Noa LibermanDivision of Newborn Medicine, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.ORCID 0000-0002-5570-3358
Zach K O'BrownDivision of Newborn Medicine, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.ORCID 0000-0003-1978-934X
Andrew Scott EarlDivision of Newborn Medicine, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.ORCID 0000-0002-5732-954X
Konstantinos BouliasDivision of Newborn Medicine, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Maxim V GerashchenkoDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-8396-2202
Simon Yuan WangDivision of Newborn Medicine, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.ORCID 0000-0002-9089-2617
Colette FritscheDivision of Newborn Medicine, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.ORCID 0000-0001-9534-8293
Paul-Enguerrand FadyDivision of Newborn Medicine, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.ORCID 0000-0002-8442-1966
Anna DongDivision of Newborn Medicine, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Vadim N GladyshevDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-0372-7016
Eric Lieberman GreerDivision of Newborn Medicine, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.ORCID 0000-0002-7501-7371
Boston Children's Hospital · USBrigham and Women's Hospital · US

Funding

Training Program in Newborn and Developmental DiseasesT32HD007466 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI KOUREMBANAS, STELLA · 1994 to 2016
$8.0M
Characterization of DNA N6-methyl adenine and its role in epigenetic memoryDP2AG055947 · NIA · BOSTON CHILDREN'S HOSPITAL · PI GREER, ERIC LIEBERMAN · 2016 to 2021
$3.2M
Identifying the molecular mechanisms of transgenerational epigenetic inheritanceR00AG043550 · NIA · BOSTON CHILDREN'S HOSPITAL · PI GREER, ERIC LIEBERMAN · 2015 to 2017
$737k
Base-resolution sequencing of 6mA in eukaryotic DNAR21HG010066 · NHGRI · BOSTON CHILDREN'S HOSPITAL · PI GREER, ERIC LIEBERMAN · 2018 to 2019
$487k
NHGRI NIH HHS R21 HG010066NIA NIH HHS DP2 AG055947NIA NIH HHS R00 AG043550NICHD NIH HHS T32 HD007466
6 · The paper itself

Abstract

During stress, global translation is reduced, but specific transcripts are actively translated. How stress-responsive mRNAs are selectively translated is unknown. We show that METL-5 methylates adenosine 1717 on 18

Identifiers

PMID32494643
PMCPMC7176415
OpenAlexW3019196011

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.