Evidence map›Paper›PMID 32494613›Full record

ArticleScience advances2020

Commensal epitopes drive differentiation of colonic T

Michal P Kuczma, Edyta A Szurek, Anna Cebula, Benoit Chassaing, Yu-Jin Jung, Sang-Moo Kang, James G Fox, Bärbel Stecher, Leszek Ignatowicz

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. The OMMGut microbes · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. M cell-dependent commensal uptake confers encephalitogenic phenotypes on γδT17 cells in Peyer's patches.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  10. Neonatal liver niches program T cell tolerance.bioRxiv : the preprint server for biology · 2026
    Article
  11. Review
  12. PasteurizedFrontiers in immunology · 2026
    Article
  13. Article
  14. Review
  15. The Biology ofAnnual review of microbiology · 2025
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Michal P KuczmaInstitute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.ORCID 0000-0003-2310-3590
Edyta A SzurekInstitute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.ORCID 0000-0002-9910-0698
Anna CebulaInstitute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.ORCID 0000-0002-7868-6845
Benoit ChassaingInstitute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.ORCID 0000-0002-4285-769X
Yu-Jin JungInstitute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.ORCID 0000-0002-1633-9135
Sang-Moo KangInstitute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.ORCID 0000-0001-6198-331X
James G FoxDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0001-9307-6116
Bärbel StecherMax-von-Pettenkofer Institute, LMU Munich, Pettenkoferstr. 9a, Munich, Germany.ORCID 0000-0002-7445-5193
Leszek IgnatowiczInstitute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.ORCID 0000-0001-8666-0381
Georgia State University · USGerman Center for Infection Research · DEInserm · FRMassachusetts Institute of Technology · US

Funding

TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YAFFE, MICHAEL B · 1985 to 2020
$25.6M
Project 3 - Molecular Signatures of Gastric Carcinogenesis in the Host Response to H. pyloriP01CA028842 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WILSON, KEITH T. · 1985 to 2019
$15.8M
The Role of Stem Cells and the Microenvironment in Gastrointestinal CancersR35CA210088 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Timothy Cragin Wang · 2017 to 2026
$10.2M
National Gnotobiotic Rodent Resource CenterP40OD010995 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ryan B Sartor · 2012 to 2026
$9.7M
Antigenic specificities of intestinal CD4+Foxp3+ T cells.R01AI121151 · NIAID · GEORGIA STATE UNIVERSITY · PI IGNATOWICZ, LESZEK · 2016 to 2020
$1.9M
Role of CD4+T cells in maintenance of intestinal homeostasisR01DK099264 · NIDDK · GEORGIA STATE UNIVERSITY · PI IGNATOWICZ, LESZEK · 2014 to 2017
$1.3M
NCI NIH HHS P01 CA028842NCI NIH HHS R35 CA210088NIAID NIH HHS R01 AI121151NIDDK NIH HHS R01 DK099264NIEHS NIH HHS P30 ES002109NIH HHS P40 OD010995
6 · The paper itself

Abstract

The gut microbiome is the largest source of intrinsic non-self-antigens that are continuously sensed by the immune system but typically do not elicit lymphocyte responses. CD4

Identifiers

PMID32494613
PMCPMC7164940
OpenAlexW3016775161

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.