Evidence map›Paper›PMID 32494600›Full record

ArticleScience advances2020

Super-resolution imaging reveals the nanoscale organization of metabotropic glutamate receptors at presynaptic active zones.

Sana Siddig, Sarah Aufmkolk, Sören Doose, Marie-Lise Jobin, Christian Werner, Markus Sauer, Davide Calebiro

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 69 citations in OpenAlex.

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  4. Nanoscale architecture and dynamics of CaJournal of molecular and cellular cardiology plus · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 5 countries.

Sana SiddigInstitute of Pharmacology and Toxicology and Bio-Imaging Center, University of Würzburg, Würzburg, Germany.ORCID 0000-0001-9982-2191
Sarah AufmkolkDepartment of Biotechnology and Biophysics, Biocenter, University of Würzburg, Würzburg, Germany.ORCID 0000-0002-0745-6022
Sören DooseDepartment of Biotechnology and Biophysics, Biocenter, University of Würzburg, Würzburg, Germany.ORCID 0000-0002-6983-1182
Marie-Lise JobinInstitute of Pharmacology and Toxicology and Bio-Imaging Center, University of Würzburg, Würzburg, Germany.
Christian WernerDepartment of Biotechnology and Biophysics, Biocenter, University of Würzburg, Würzburg, Germany.
Markus SauerDepartment of Biotechnology and Biophysics, Biocenter, University of Würzburg, Würzburg, Germany.ORCID 0000-0002-1692-3219
Davide CalebiroInstitute of Pharmacology and Toxicology and Bio-Imaging Center, University of Würzburg, Würzburg, Germany.ORCID 0000-0002-3811-1553
University of Würzburg · DEMontreal Neurological Institute and Hospital · CAUniversity of Khartoum · SD

Funding

Wellcome Trust
6 · The paper itself

Abstract

G protein-coupled receptors (GPCRs) play a fundamental role in the modulation of synaptic transmission. A pivotal example is provided by the metabotropic glutamate receptor type 4 (mGluR4), which inhibits glutamate release at presynaptic active zones (AZs). However, how GPCRs are organized within AZs to regulate neurotransmission remains largely unknown. Here, we applied two-color super-resolution imaging by

Indexed as

Receptors, Metabotropic GlutamateSynapsesAnimalsMiceMicroscopySynaptic TransmissionReceptors, Metabotropic Glutamate

Identifiers

PMID32494600
PMCPMC7159906
OpenAlexW3016327039

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.