ArticleTherapeutics and clinical risk management2020
Systemic Inflammatory Response Markers Associated with Infertility and Endometrioma or Uterine Leiomyoma in Endometriosis.
Article in Therapeutics and clinical risk management, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Neutrophil-to-lymphocyte ratio and endometriosis: systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Diagnostic significance of neutrophil to lymphocyte ratio in endometriosis: a systematic review and meta-analysis.BMC women's health · 2023Pooled it
- A Systematic Review of Atypical Endometriosis-Associated Biomarkers.International journal of molecular sciences · 2022Pooled it
- Plasma-Corona Enabled Synthesis of Photonic Copper Sensor for the Detection of Ovarian Cancer Marker CA 125.Nanomaterials (Basel, Switzerland) · 2026Article
- Interleukin-6 and hormonal biomarker profiles in Moroccan women with endometriosis.Obstetrics & gynecology science · 2026Article
- Association of Peripheral Inflammatory Markers with Conception Outcomes Among Women with Endometriosis-Associated Infertility.Diagnostics (Basel, Switzerland) · 2026Article
- Investigating the association between systemic immune-inflammation index and female fertility: a retrospective cohort study.Journal of ovarian research · 2026Article
- Diagnostic Value of Serum Cancer Antigen 125, Carcinoembryonic Antigen, Cancer Antigen 19-9, Anti Müllerian Hormone, White Blood Cell Count, Platelet Count, and Neutrophil to Lymphocyte Ratio in Endometriosis: A Retrospective Study.International journal of fertility & sterility · 2025Article
- Neutrophil-to-lymphocyte ratio in females as a predictor of embryo acquisition outcomes after IVF/ICSI treatment: a retrospective study.Frontiers in endocrinology · 2025Article
- The Role of Inflammatory Markers NLR and PLR in Predicting Pelvic Pain in Endometriosis.Journal of clinical medicine · 2024Article
- Application of machine learning techniques in the diagnosis of endometriosis.BMC women's health · 2024Article
- The value of lung function assessment and Testin expression detection in clinicopathological features and prognosis of NSCLC patients.Journal of cardiothoracic surgery · 2024Article
- Role of Molecular Biomarkers in Endometriosis-Related Infertility: A Narrative Review of the Literature.Cureus · 2024Review
- Combined delta neutrophil index and red blood cell distribution width as a new biomarker to predict endometriosisJournal of the Turkish German Gynecological Association · 2024Article
- Inflammatory markers are associated with infertility prevalence: a cross-sectional analysis of the NHANES 2013-2020.BMC public health · 2024Article
- Systemic inflammatory indices as a non-invasive grading modality for endometriosis: a comparative study versus exploratory laparoscopy.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2024Article
- Inflammatory Markers in Women with Infertility: A Cross-Sectional Study.International journal of general medicine · 2023Article
- Diagnostic Accuracy of Salivary aMMP-8 Test in Infertile Women and Blood Finding Analysis.Acta stomatologica Croatica · 2022Article
- The Search for Biomarkers in Endometriosis: a Long and Windy Road.Reproductive sciences (Thousand Oaks, Calif.) · 2022Review
- Examination on Risk Factors of Infertility Caused by EMT and Their Correlation with VEGF, TNF-Contrast media & molecular imaging · 2022Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to find the most useful marker of endometriosis-related infertility and evaluate predictive and diagnostic values of systemic inflammatory response markers (preoperative white blood-cell subtypes, neutrophil:lymphocyte ratio [NLR], platelet:lymphocyte ratio [PLR], and monocyte:lymphocyte ratio [MLR]) and CA125 levels in endometriosis patients.
methodsThis study comprised 662 women who had undergone laparoscopic surgery and been pathologically confirmed as having endometriosis and 83 patients pathologically confirmed with benign ovarian tumors. Related inflammatory factors in endometriosis complicated by infertility were analyzed via logistic regression analysis. Diagnostic values of the inflammatory response markers were obtained by receiver operating-characteristic analysis.
resultsWe firstly identified that lower NLR level was an independent risk factor of infertility. Serum lymphocytes were significantly higher in endometriosis patients, while serum CA125, NLR, MLR, and PLR were elevated. For differentiating endometriosis from other benign ovarian tumors, the combination of NLR and CA125 achieved greater sensitivity than CA125 alone. In addition, both CA125 and NLR were positively correlated with stage, oviduct adhesion, and diameter of ovarian ectopic cysts.
conclusionNLR may be used as a simple and easily obtained predictive marker for endometriosis with infertility. Moreover, NLR can be a neoadjuvant biomarker for serum CA125 to diagnose endometriosis.
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