Evidence map›Paper›PMID 32494136›Full record

ArticleInternational journal of nanomedicine2020

Hepatitis C Virus NS3 Protease and Helicase Inhibitors from Red Sea Sponge (

Nourhan Hisham Shady, Amira R Khattab, Safwat Ahmed, Miaomiao Liu, Ronald J Quinn, Mostafa A Fouad, Mohamed Salah Kamel, Abdullatif Bin Muhsinah, Markus Krischke, Martin J Mueller and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 45 citations in OpenAlex.

  1. Review
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  9. Wound Healing and Antioxidant Capabilities ofPlants (Basel, Switzerland) · 2022
    Article
  10. Article
  11. Review
  12. Review
  13. Future virology · 2022
    Article
  14. Review
  15. Review
  16. Future virology · 2021
    Article
  17. Article
  18. Review
  19. Targeting 3CLpro and SARS-CoV-2 RdRp byMolecules (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 4 countries.

Nourhan Hisham ShadyDepartment of Pharmacognosy, Faculty of Pharmacy, Deraya University, Universities Zone, Minia 61111, Egypt.
Amira R KhattabDepartment of Pharmacognosy, College of Pharmacy, Arab Academy for Science, Technology and Maritime Transport, Alexandria 1029, Egypt.ORCID 0000-0002-8768-7874
Safwat AhmedDepartment of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt 41522.
Miaomiao LiuGriffith Institute for Drug Discovery, Griffith University, Brisbane, Queensland 4111, Australia.
Ronald J QuinnGriffith Institute for Drug Discovery, Griffith University, Brisbane, Queensland 4111, Australia.ORCID 0000-0002-4022-2623
Mostafa A FouadDepartment of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
Mohamed Salah KamelDepartment of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
Abdullatif Bin MuhsinahDepartment of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 61441, Saudi Arabia.ORCID 0000-0002-9742-3573
Markus KrischkeDepartment of Pharmaceutical Biology, Julius-von-Sachs Institute for Biological Sciences, University of Würzburg, Würzburg 97082, Germany.
Martin J MuellerDepartment of Pharmaceutical Biology, Julius-von-Sachs Institute for Biological Sciences, University of Würzburg, Würzburg 97082, Germany.
Usama Ramadan AbdelmohsenDepartment of Pharmacognosy, Faculty of Pharmacy, Deraya University, Universities Zone, Minia 61111, Egypt.
Deraya UniversityGriffith University · AUMinia University · EGUniversity of Würzburg · DEArab Academy for Science, Technology, and Maritime Transport · EGKing Khalid University · SASuez Canal University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatitis C virus (HCV) infection is a major cause of hepatic diseases all over the world. This necessitates the need to discover novel anti-HCV drugs to overcome emerging drug resistance and liver complications. PURPOSE: Total extract and petroleum ether fraction of the marine sponge (

methodsCharacterization of the prepared SNPs was carried out with ultraviolet-visible spectroscopy, transmission electron microscopy, and Fourier-transform infrared spectroscopy. The metabolomic profile of different

resultsTransmission electron-microscopy analysis of NPs prepared from

conclusionOur findings indicate that

Indexed as

Computer SimulationGreen Chemistry TechnologyMetabolomicsAlkanesAnimalsAntiviral AgentsDEAD-box RNA HelicasesDNA HelicasesHepacivirusIndian OceanMetal NanoparticlesMolecular Docking SimulationNucleoside-TriphosphatasePeptide HydrolasesPoriferaProtease InhibitorsAlkanesAntiviral AgentsDEAD-box RNA HelicasesDNA HelicasesnaphthaNS3 protein, hepatitis C virusNucleoside-TriphosphatasePeptide HydrolasesProtease InhibitorsSerine EndopeptidasesSilverViral Nonstructural ProteinsViral ProteasesAmphimedonHCV helicasemarine spongemetabolomicsmolecular dockingnanoparticlesnatural productsprotease

Identifiers

PMID32494136
PMCPMC7231760
OpenAlexW3023835400

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.