Evidence map›Paper›PMID 32494133›Full record

ArticleInternational journal of nanomedicine2020

ROS-Responsive Chitosan Coated Magnetic Iron Oxide Nanoparticles as Potential Vehicles for Targeted Drug Delivery in Cancer Therapy.

Srinivasan Ayyanaar, Chandrasekar Balachandran, Rangaswamy Chinnabba Bhaskar, Mookkandi Palsamy Kesavan, Shin Aoki, Ramachandran Palpandi Raja, Jegathalaprathaban Rajesh, Thomas J Webster, Gurusamy Rajagopal

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Magnetic nanoparticles for cancer theranostics.Biomedical physics & engineering express · 2026
    Review
  4. Stimuli-responsive bioengineered platforms for precision cancer therapy.Frontiers in bioengineering and biotechnology · 2026
    Review
  5. Design, characterization, andRSC advances · 2025
    Article
  6. Article
  7. Biocompatible gelatin-coated ferrite nanoparticles: A magnetic approach to advanced drug delivery.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. CuO-TiOBioinorganic chemistry and applications · 2022
    Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Srinivasan AyyanaarPG and Research Department of Chemistry, Chikkanna Government Arts College, Tiruppur 641 602, Tamilnadu, India.
Chandrasekar BalachandranFaculty of Pharmaceutical Sciences, Tokyo University of Science, Noda 278-8510, Japan.
Rangaswamy Chinnabba BhaskarDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, India.
Mookkandi Palsamy KesavanDepartment of Chemistry, Hajee Karutha Rowther Howdia College, Uthamapalayam 625 533, Tamil Nadu, India.
Shin AokiFaculty of Pharmaceutical Sciences, Tokyo University of Science, Noda 278-8510, Japan.ORCID 0000-0002-4287-6487
Ramachandran Palpandi RajaCentre for Biotechnology, Anna University, Chennai 600 025, Tamil Nadu, India.
Jegathalaprathaban RajeshChemistry Research Centre, Mohamed Sathak Engineering College, Kilakarai 623 806, Tamil Nadu, India.
Thomas J WebsterDepartment of Chemical Engineering, Northeastern University, Boston, MA 02115, USA.ORCID 0000-0002-2028-5969
Gurusamy RajagopalPG and Research Department of Chemistry, Chikkanna Government Arts College, Tiruppur 641 602, Tamilnadu, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveCancer cells accumulate high concentrations of reactive oxygen species as a result of their faster and uninhibited metabolic activity. Cancer chemotherapeutic agents release an excess of severe adverse reactions as a result of targeting normal cells. This demands an improvement in targeted drug-delivery systems to selectively discharge anticancer drugs in the vicinity of such highly metabolically and mitotically active cells. MATERIALS AND

methodsHere, magnetic nanoparticles were synthesized by a traditional co-precipitation technique. Fe

resultsThe targeted drug release profile of the Fe

conclusionIn summary, results from the MTT assay, fluorescence staining as well as colony formation assays, revealed that the Fe

Indexed as

Drug Delivery SystemsAntineoplastic AgentsCell DeathCell Line, TumorChitosanDrug CarriersDrug LiberationFerric CompoundsFluorouracilHumansHydrogen-Ion ConcentrationInhibitory Concentration 50Magnetite NanoparticlesNeoplasmsOleic AcidParticle SizeAntineoplastic AgentsChitosanDrug CarriersFerric Compoundsferric oxideFluorouracilMagnetite NanoparticlesOleic AcidReactive Oxygen Species5-fluorouracilchitosancytotoxicitymagnetic iron oxide nanoparticlesoleic acidtargeted drug delivery

Identifiers

PMID32494133
PMCPMC7229795

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.