Evidence map›Paper›PMID 32494070›Full record

ArticleNature2020

LEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation.

Alexander von Appen, Dollie LaJoie, Isabel E Johnson, Michael J Trnka, Sarah M Pick, Alma L Burlingame, Katharine S Ullman, Adam Frost

Open access · greenAbstract read
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 152 citations in OpenAlex.

  1. Review
  2. Review
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  4. Review
  5. Article
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  9. Article
  10. Article
  11. Article
  12. Capillary bundling of microtubules by condensates.bioRxiv : the preprint server for biology · 2026
    Article
  13. Article
  14. Article
  15. Membrane interaction of cyanobacterial and chloroplast ESCRT-III proteins.The Plant journal : for cell and molecular biology · 2026
    Review
  16. Article
  17. Review
  18. Article
  19. Structure, function and assembly of nuclear pore complexes.Nature reviews. Molecular cell biology · 2026
    Review
  20. Review

56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Alexander von Appen *Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6528-2123
Dollie LaJoie *Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Isabel E Johnson *Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3294-4423
Michael J TrnkaDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-8808-5146
Sarah M PickFaculty of Chemistry and Pharmacy, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0001-5091-2719
Alma L BurlingameDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
Katharine S UllmanDepartment of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. katharine.ullman@hci.utah.edu.
Adam FrostDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA, USA. adam.frost@ucsf.edu.ORCID http://orcid.org/0000-0003-2231-2577
University of California, San Francisco · USUniversity of Utah · USQB3 · USUniversity of Freiburg · DE

Funding

UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI KATHARINE S ULLMAN · 1986 to 2026
$72.6M
X-ray Cryst. CoreP50GM082545 · NIGMS · UNIVERSITY OF UTAH · PI SUNDQUIST, WESLEY I. · 2007 to 2018
$51.1M
Virus TransmissionP50AI150464 · NIAID · UNIVERSITY OF UTAH · PI SUNDQUIST, WESLEY I. · 2019 to 2021
$14.9M
Toward Atomic Resolution of Membranes and Membrane-Associated MachinesDP2GM110772 · NIGMS · UNIVERSITY OF UTAH · PI FROST, ADAM · 2013 to 2013
$2.2M
Dynamic Events at the Nuclear Envelope during Mitosis and InterphaseR01GM131052 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ULLMAN, KATHARINE S · 2019 to 2025
$2.1M
Purchase of Q-Exactive Mass SpectrometerS10OD016229 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURLINGAME, ALMA L · 2013 to 2013
$507k
NCI NIH HHS P30 CA042014NIAID NIH HHS P50 AI150464NIGMS NIH HHS DP2 GM110772NIGMS NIH HHS P50 GM082545NIGMS NIH HHS R01 GM131052NIH HHS 1DP2-GM110772NIH HHS 1R01-GM31052NIH HHS S10 OD016229
6 · The paper itself

Abstract

During cell division, remodelling of the nuclear envelope enables chromosome segregation by the mitotic spindle

Indexed as

AnaphaseChromatinDNA-Binding ProteinsDNA DamageEndosomal Sorting Complexes Required for TransportHeLa CellsHumansMembrane ProteinsMicrotubulesNuclear EnvelopeNuclear ProteinsSpindle ApparatusBANF1 protein, humanCHMP7 protein, humanChromatinDNA-Binding ProteinsEndosomal Sorting Complexes Required for TransportLEMD2 protein, humanMembrane ProteinsNuclear Proteins

Identifiers

PMID32494070
PMCPMC7321842
OpenAlexW3023017507

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.