ArticleInternational journal of obesity (2005)2020
Birth weight, cardiometabolic risk factors and effect modification of physical activity in children and adolescents: pooled data from 12 international studies.
Article in International journal of obesity (2005), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 23 citations in OpenAlex.
- Food selection, cardiorespiratory fitness and the longitudinal association with adiposity among South African school children: the ExAMIN Youth SA study.European journal of clinical nutrition · 2026Article
- A computational model to analyze the impact of birth weight-nutritional status pair on disease development and disease recovery.Health information science and systems · 2024Article
- The impact of macrosomia on cardiometabolic health in preteens: findings from the ROLO longitudinal birth cohort study.Nutrition & metabolism · 2023Article
- Evening blue-light exposure, maternal glucose, and infant birthweight.Annals of the New York Academy of Sciences · 2022Article
- Association between Objectively Determined Physical Activity Levels and Body Composition in 6-8-Year-Old Children from a Black South African Population: BC-IT Study.International journal of environmental research and public health · 2021Article
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Authors and funding
18 authors at 11 institutions in 7 countries.
Funding
Abstract
objectivesLow and high birth weight is associated with higher levels of cardiometabolic risk factors and adiposity in children and adolescents, and increases the risk of cardiovascular diseases, obesity, and early mortality later in life. Moderate-to-vigorous physical activity (MVPA) is associated with lower cardiometabolic risk factors and may mitigate the detrimental consequences of high or low birth weight. Thus, we examined whether MVPA modified the associations between birth weight and cardiometabolic risk factors in children and adolescents.
methodsWe used pooled individual data from 12 cohort- or cross-sectional studies including 9,100 children and adolescents. Birth weight was measured at birth or maternally reported retrospectively. Device-measured physical activity (PA) and cardiometabolic risk factors were measured in childhood or adolescence. We tested for associations between birth weight, MVPA, and cardiometabolic risk factors using multilevel linear regression, including study as a random factor. We tested for interaction between birth weight and MVPA by introducing the interaction term in the models (birth weight x MVPA).
resultsMost of the associations between birth weight (kg) and cardiometabolic risk factors were not modified by MVPA (min/day), except between birth weight and waist circumference (cm) in children (p = 0.005) and HDL-cholesterol (mmol/l) in adolescents (p = 0.040). Sensitivity analyses suggested that some of the associations were modified by VPA, i.e., the associations between birth weight and diastolic blood pressure (mmHg) in children (p = 0.009) and LDL- cholesterol (mmol/l) (p = 0.009) and triglycerides (mmol/l) in adolescents (p = 0.028).
conclusionMVPA appears not to consistently modify the associations between low birth weight and cardiometabolic risk. In contrast, MVPA may mitigate the association between higher birth weight and higher waist circumference in children. MVPA is consistently associated with a lower cardiometabolic risk across the birth weight spectrum. Optimal prenatal growth and subsequent PA are both important in relation to cardiometabolic health in children and adolescents.
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