Evidence map›Paper›PMID 32494014›Full record

ArticleNature2020

Insights into variation in meiosis from 31,228 human sperm genomes.

Avery Davis Bell, Curtis J Mello, James Nemesh, Sara A Brumbaugh, Alec Wysoker, Steven A McCarroll

Open access · greenAbstract read
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
14.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 121 citations in OpenAlex.

  1. Article
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  7. Ufd2p promotes efficient crossover formation by destabilizing Top2p during meiosis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Article
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  11. Human acrocentric chromosome short armbioRxiv : the preprint server for biology · 2025
    Article
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  13. Review
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  15. Review
  16. Article
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  18. Article
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Avery Davis BellDepartment of Genetics, Harvard Medical School, Boston, MA, USA. averydavisbell@gmail.com.ORCID http://orcid.org/0000-0002-1837-302X
Curtis J MelloDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
James NemeshDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Sara A BrumbaughDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Alec WysokerDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Steven A McCarrollDepartment of Genetics, Harvard Medical School, Boston, MA, USA. mccarroll@genetics.med.harvard.edu.
Broad Institute · US

Funding

Structurally complex genome loci in human populations and human phenotypesR01HG006855 · NHGRI · HARVARD MEDICAL SCHOOL · PI Steven Andrew McCarroll · 2012 to 2026
$8.2M
NHGRI NIH HHS R01 HG006855
6 · The paper itself

Abstract

Meiosis, although essential for reproduction, is also variable and error-prone: rates of chromosome crossover vary among gametes, between the sexes, and among humans of the same sex, and chromosome missegregation leads to abnormal chromosome numbers (aneuploidy)

Indexed as

AdolescentAdultAllelesAneuploidyCrossing Over, GeneticGenome, HumanHaplotypesHumansMaleMeiosisNondisjunction, GeneticSingle-Cell AnalysisSpermatozoaTissue DonorsYoung Adult

Identifiers

PMID32494014
PMCPMC7351608
OpenAlexW3030801603

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.