Evidence map›Paper›PMID 32494013›Full record

ArticleNature2020

Hair-bearing human skin generated entirely from pluripotent stem cells.

Jiyoon Lee, Cyrus C Rabbani, Hongyu Gao, Matthew R Steinhart, Benjamin M Woodruff, Zachary E Pflum, Alexander Kim, Stefan Heller, Yunlong Liu, Taha Z Shipchandler and 1 more

Open access · greenAbstract read
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 294 papers.

0numbers the graph read from it
0cells of the map it votes in
294citing papers in PubMed
19.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

294 citing papers in PubMed, 430 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. New developments and applications of human organoids.Nature reviews. Molecular cell biology · 2026
    Review
  16. Highly Biomimetic Ectodermal Epithelial Organoids for Epithelial Barrier Stimulation Assays.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  17. Article
  18. Review
  19. Article
  20. Article

234 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Jiyoon LeeDepartment of Otolaryngology, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5561-5331
Cyrus C RabbaniDepartment of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Hongyu GaoCenter for Medical Genomics, Indiana University School of Medicine, Indianapolis, IN, USA.
Matthew R SteinhartF. M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9619-6057
Benjamin M WoodruffDepartment of Otolaryngology, Stanford University, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0003-3045-4196
Zachary E PflumDepartment of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Alexander KimDepartment of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Stefan HellerDepartment of Otolaryngology, Stanford University, Palo Alto, CA, USA.
Yunlong LiuCenter for Medical Genomics, Indiana University School of Medicine, Indianapolis, IN, USA.
Taha Z ShipchandlerDepartment of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Karl R KoehlerDepartment of Otolaryngology, Boston Children's Hospital, Boston, MA, USA. karl.koehler@childrens.harvard.edu.ORCID http://orcid.org/0000-0002-0685-538X
Indiana University School of MedicineBoston Children's Hospital · USStanford University · USJohns Hopkins University · US

Funding

Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
LABORATORY OF DEVELOPMENTAL BIOLOGYR24HD000836 · NICHD · UNIVERSITY OF WASHINGTON · PI Ian Amos Glass · 1995 to 2026
$16.9M
Engineering multi-lineage inner ear organoidsR01DC017461 · NIDCD · INDIANA UNIVERSITY INDIANAPOLIS · PI Karl Russell Koehler · 2019 to 2026
$4.7M
EXTRAMURAL RESEARCH FACILITIES IMPROVEMENT: NEUROLOGICAL DISORDERS:ALZ, PDC06RR020128 · NCRR · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI FIFE, ROSE S · 2004 to 2004
$3.7M
Generation of human skin organoids from pluripotency (Admin Supplement)R01AR075018 · NIAMS · BOSTON CHILDREN'S HOSPITAL · PI Karl Russell Koehler · 2019 to 2026
$3.6M
Modeling Otic Neurogenesis in Human Stem Cell-Derived OrganoidsR03DC015624 · NIDCD · INDIANA UNIVERSITY INDIANAPOLIS · PI KOEHLER, KARL RUSSELL · 2016 to 2018
$471k
NCATS NIH HHS UL1 TR001108NCRR NIH HHS C06 RR020128NIAMS NIH HHS R01 AR075018NICHD NIH HHS R24 HD000836NIDCD NIH HHS R01 DC017461NIDCD NIH HHS R03 DC015624NIH HHS 5R24HD000836NIH HHS C06 RR020128-01
6 · The paper itself

Abstract

The skin is a multilayered organ, equipped with appendages (that is, follicles and glands), that is critical for regulating body temperature and the retention of bodily fluids, guarding against external stresses and mediating the sensation of touch and pain

Indexed as

AnimalsEctodermFemaleHairHair ColorHair FollicleHeadHeterograftsHumansMiceMice, NudeOrganoidsPluripotent Stem CellsRNA-SeqSingle-Cell AnalysisSkin

Identifiers

PMID32494013
PMCPMC7593871
OpenAlexW3032142305

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.