Evidence map›Paper›PMID 32494007›Full record

ArticleNature2020

IGF1R is an entry receptor for respiratory syncytial virus.

Cameron D Griffiths, Leanne M Bilawchuk, John E McDonough, Kyla C Jamieson, Farah Elawar, Yuchen Cen, Wenming Duan, Cindy Lin, Haeun Song, Jean-Laurent Casanova and 8 more

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 130 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed, 2 pooled it
14.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

130 citing papers in PubMed, 2 syntheses or guidelines pooled it, 199 citations in OpenAlex.

  1. Pooled it
  2. Frontiers in immunology · 2021
    Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Unique nasal cell states induced by common pediatric respiratory viruses.bioRxiv : the preprint server for biology · 2026
    Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  18. Article
  19. Article
  20. Article

70 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 4 countries.

Cameron D Griffiths *Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta, Canada.ORCID http://orcid.org/0000-0002-1280-3615
Leanne M Bilawchuk *Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta, Canada.
John E McDonoughSection of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USA.
Kyla C JamiesonDepartment of Physiology and Pharmacology, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Farah ElawarLi Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta, Canada.
Yuchen CenProgram of Translational Medicine, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
Wenming DuanProgram of Translational Medicine, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
Cindy LinProgram of Translational Medicine, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
Haeun SongProgram of Translational Medicine, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
Jean-Laurent CasanovaSt Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Steven OggLi Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta, Canada.
Lionel Dylan JensenLi Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta, Canada.
Bernard ThienpontLaboratory for Functional Epigenetics, Department of Human Genetics, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-8772-6845
Anil KumarLi Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta, Canada.ORCID http://orcid.org/0000-0002-6179-4516
Tom C HobmanLi Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta, Canada.
David ProudDepartment of Physiology and Pharmacology, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID http://orcid.org/0000-0001-9629-6595
Theo J MoraesProgram of Translational Medicine, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
David J MarchantLi Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta, Canada. marchant@ualberta.ca.
University of Alberta · CAHospital for Sick Children · CAUniversity of Calgary · CAHoward Hughes Medical Institute · USKU Leuven · BEUniversity of Toronto · CAYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pneumonia resulting from infection is one of the leading causes of death worldwide. Pulmonary infection by the respiratory syncytial virus (RSV) is a large burden on human health, for which there are few therapeutic options

Indexed as

Virus InternalizationCell LineCell NucleusEnzyme ActivationHumansMembrane FusionNucleolinPhosphoproteinsProtein BindingProtein Kinase CProtein Kinase C zetaReceptor, IGF Type 1Receptors, VirusRespiratory Syncytial VirusesRNA-Binding ProteinsViral LoadIGF1R protein, humanNucleolinPhosphoproteinsProtein Kinase CProtein Kinase C zetaReceptor, IGF Type 1Receptors, VirusRNA-Binding Proteins

Identifiers

PMID32494007
OpenAlexW3032889003

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.