ArticleSpinal cord2021
Development and deployment of an at-home strength and conditioning program to support a phase I trial in persons with chronic spinal cord injury.
Article in Spinal cord, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02354625 (The Safety of Autologous Human Schwann Cells), which is not on this map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Safety of Autologous Human Schwann Cells (ahSC) in Subjects With Chronic Spinal Cord Injury (SCI) Receiving Rehabilitation
Who cites it
7 citing papers in PubMed.
- Global trends in scientific production on physical exercise and spinal cord injury.Frontiers in sports and active living · 2025Review
- Bridging the gap: a translational perspective in spinal cord injury.Experimental biology and medicine (Maywood, N.J.) · 2024Review
- Review
- Phase 1 Safety Trial of Autologous Human Schwann Cell Transplantation in Chronic Spinal Cord Injury.Journal of neurotrauma · 2022Article
- Cell transplantation to repair the injured spinal cord.International review of neurobiology · 2022Article
- Current progress of rehabilitative strategies in stem cell therapy for spinal cord injury: a review.NPJ Regenerative medicine · 2021Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
STUDY
designNonrandomized clinical trial (NCT02354625).
objectivesAs a part of a Phase I clinical trial to assess the safety of autologous human Schwann cells (ahSC) in persons with chronic spinal cord injury (SCI), participants engaged in a multimodal conditioning program pre- and post-ahSC transplantation. The program included a home-based strength and endurance training program to prevent lack of fitness and posttransplantation detraining from confounding potential ahSC therapeutic effects. This paper describes development, deployment, outcomes, and challenges of the home-based training program.
settingUniversity-based laboratory.
methodsDevelopment phase: two men with paraplegia completed an 8-week laboratory-based 'test' of the home-based program. Deployment phase: the first four (two males, two females) participant cohort of the ahSC trial completed the program at home for 12 weeks pre and 20 weeks post ahSC transplant.
resultsDevelopment phase: both participants improved their peak aerobic capacity (VO
Indexed as
Identifiers
32493977What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.