Evidence map›Paper›PMID 32493925›Full record

ArticleNature communications2020

The characterization of Mediator 12 and 13 as conditional positive gene regulators in Arabidopsis.

Qikun Liu, Sylvain Bischof, C Jake Harris, Zhenhui Zhong, Lingyu Zhan, Calvin Nguyen, Andrew Rashoff, William D Barshop, Fei Sun, Suhua Feng and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
10.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Principles and mechanisms of plant acclimation to heat stress.Nature reviews. Molecular cell biology · 2026
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  16. The MOM1 complex recruits the RdDM machinery via MORC6 to establishbioRxiv : the preprint server for biology · 2023
    Article
  17. Article
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  19. Article
  20. The role of ATXR6 expression in modulating genome stability and transposable element repression inProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 3 countries.

Qikun Liu *School of Advanced Agricultural Sciences, Peking University, 100871, Beijing, China. qikunliu@pku.edu.cn.ORCID http://orcid.org/0000-0003-2489-2907
Sylvain Bischof *Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA, 90095, USA.
C Jake HarrisDepartment of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA, 90095, USA.
Zhenhui ZhongDepartment of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA, 90095, USA.ORCID http://orcid.org/0000-0002-8438-0375
Lingyu ZhanDepartment of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA, 90095, USA.
Calvin NguyenDepartment of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA, 90095, USA.ORCID http://orcid.org/0000-0001-8382-9305
Andrew RashoffDepartment of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA, 90095, USA.
William D BarshopDepartment of Biological Chemistry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, 90095, USA.
Fei SunDepartment of Biological Chemistry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, 90095, USA.
Suhua FengDepartment of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA, 90095, USA.
Magdalena PotokDepartment of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA, 90095, USA.
Javier Gallego-BartolomeDepartment of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA, 90095, USA.
Jixian ZhaiInstitute of Plant and Food Science, Department of Biology, Southern University of Science and Technology, Shenzhen, China.ORCID http://orcid.org/0000-0002-0217-0666
James A WohlschlegelDepartment of Biological Chemistry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, 90095, USA.
Michael F CareyDepartment of Biological Chemistry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, 90095, USA.
Jeffrey A LongDepartment of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA, 90095, USA.
Steven E JacobsenDepartment of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA, 90095, USA. jacobsen@ucla.edu.ORCID http://orcid.org/0000-0001-9483-138X
University of California, Los Angeles · USHoward Hughes Medical Institute · USSouthern University of Science and Technology · CN

Funding

UCLA NIGMS T32 Program AssessmentT32GM007185 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TORRES, JORGE · 1985 to 2020
$21.7M
Interplay Between Chromatin and Co-Activator ComplexesR01GM074701 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAREY, MICHAEL F · 2005 to 2025
$6.7M
Proteolytic Control of Iron Metabolism by the Ubiquitin Ligase FBXL5R01GM089778 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WOHLSCHLEGEL, JAMES AKIRA · 2010 to 2023
$4.0M
Mechanisms of Transcriptional Repression in ArabidopsisR01GM072764 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LONG, JEFFREY A · 2004 to 2013
$3.4M
Epigenetic gene regulation in ArabidopsisR35GM130272 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JACOBSEN, STEVEN E · 2019 to 2023
$1.6M
Characterization of factors required for expression of DNA methylated genesF32GM122350 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIU, QIKUN · 2017 to 2017
$57k
Howard Hughes Medical InstituteNIGMS NIH HHS F32 GM122350NIGMS NIH HHS R01 GM072764NIGMS NIH HHS R01 GM074701NIGMS NIH HHS R01 GM089778NIGMS NIH HHS R35 GM130272NIGMS NIH HHS T32 GM007185
6 · The paper itself

Abstract

Mediator 12 (MED12) and MED13 are components of the Mediator multi-protein complex, that facilitates the initial steps of gene transcription. Here, in an Arabidopsis mutant screen, we identify MED12 and MED13 as positive gene regulators, both of which contribute broadly to morc1 de-repressed gene expression. Both MED12 and MED13 are preferentially required for the expression of genes depleted in active chromatin marks, a chromatin signature shared with morc1 re-activated loci. We further discover that MED12 tends to interact with genes that are responsive to environmental stimuli, including light and radiation. We demonstrate that light-induced transient gene expression depends on MED12, and is accompanied by a concomitant increase in MED12 enrichment during induction. In contrast, the steady-state expression level of these genes show little dependence on MED12, suggesting that MED12 is primarily required to aid the expression of genes in transition from less-active to more active states.

Indexed as

Gene Expression Regulation, PlantArabidopsisArabidopsis ProteinsChromatinDNA MethylationEpigenesis, GeneticGenes, PlantGenes, SuppressorGenetic LociGreen Fluorescent ProteinsLightPlants, Genetically ModifiedRepressor ProteinsUp-RegulationArabidopsis ProteinsCENTRAL CITY protein, ArabidopsisChromatinGRAND CENTRAL protein, ArabidopsisGreen Fluorescent ProteinsRepressor Proteins

Identifiers

PMID32493925
PMCPMC7271234
OpenAlexW3031651235

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.