Evidence map›Paper›PMID 32493740›Full record

SynthesisCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2020

Efficacy and safety of antiviral treatment for COVID-19 from evidence in studies of SARS-CoV-2 and other acute viral infections: a systematic review and meta-analysis.

Wei Liu, Pengxiang Zhou, Ken Chen, Zhikang Ye, Fang Liu, Xiaotong Li, Na He, Ziyang Wu, Qi Zhang, Xuepeng Gong and 12 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 13 pooled it
2.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 13 syntheses or guidelines pooled it, 87 citations in OpenAlex.

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  14. Trial
  15. Article
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  20. Efficacy and safety of convalescent plasma therapy in SARS-CoV2 patients on hemodialysis.Hemodialysis international. International Symposium on Home Hemodialysis · 2021
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 5 institutions in 1 country.

Wei LiuDepartment of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Pengxiang ZhouDepartment of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Ken ChenDepartment of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Zhikang YeDepartment of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Fang LiuDepartment of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Xiaotong LiDepartment of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Na HeDepartment of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Ziyang WuDepartment of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Qi ZhangDepartment of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Xuepeng GongDepartment of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Qiyu TangDepartment of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Xin DuDepartment of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Yingqiu YingDepartment of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Xiaohan XuDepartment of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Yahui ZhangDepartment of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Jinyu LiuDepartment of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Yun LiDepartment of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Ning ShenDepartment of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Rachel J CoubanDepartment of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Quazi I IbrahimDepartment of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Gordon GuyattDepartment of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Suodi ZhaiDepartment of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China zhaisuodi@163.com.
Tongji Hospital · CNPeking University · CNPeking University Third Hospital · CNFirst Hospital of Shanxi Medical University · CNShanxi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntiviral medications are being given empirically to some patients with coronavirus disease 2019 (COVID-19). To support the development of a COVID-19 management guideline, we conducted a systematic review that addressed the benefits and harms of 7 antiviral treatments for COVID-19.

methodsWe searched MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), PubMed and 3 Chinese databases (CNKI, WANFANG and SinoMed) through Apr. 19, medRxiv and Chinaxiv through Apr. 27, and Chongqing VIP through Apr. 30, 2020. We included studies of ribavirin, chloroquine, hydroxychloroquine, umifenovir (arbidol), favipravir, interferon and lopinavir/ritonavir. If direct evidence from COVID-19 studies was not available, we included indirect evidence from studies of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) for efficacy outcomes and other acute respiratory viral infections for safety outcomes.

resultsIn patients with nonsevere COVID-19 illness, the death rate was extremely low, precluding an important effect on mortality. We found only very low-quality evidence with little or no suggestion of benefit for most treatments and outcomes in both nonsevere and severe COVID-19. An exception was treatment with lopinavir/ritonavir, for which we found low-quality evidence for a decrease in length of stay in the intensive care unit (risk difference 5 d shorter, 95% confidence interval [CI] 0 to 9 d) and hospital stay (risk difference 1 d shorter, 95% CI 0 to 2 d). For safety outcomes, evidence was of low or very low quality, with the exception of treatment with lopinavir/ritonavir for which moderate-quality evidence suggested likely increases in diarrhea, nausea and vomiting.

interpretationTo date, persuasive evidence of important benefit in COVID-19 does not exist for any antiviral treatments, although for each treatment evidence has not excluded important benefit. Additional randomized controlled trials involving patients with COVID-19 will be needed before such treatments can be administered with confidence.

Indexed as

Antiviral AgentsAmidesBetacoronavirusChloroquineCoronavirus InfectionsCOVID-19COVID-19 Drug TreatmentEvidence-Based MedicineHumansHydroxychloroquineIndolesInfluenza, HumanLopinavirObservational Studies as TopicPandemicsPneumonia, ViralAmidesAntiviral AgentsChloroquinefavipiravirHydroxychloroquineIndolesLopinavirPyrazinesRibavirinRitonavirSulfidesumifenovir

Identifiers

PMID32493740
PMCPMC7828899
OpenAlexW3029004538

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.