ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Mediodorsal Thalamus Contributes to the Timing of Instrumental Actions.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Mediodorsal thalamus of alcohol-dependent mice shows genetic and physiological adaptations and alcohol-biased calcium signaling.Neuropharmacology · 2026Article
- Distinct mediodorsal-prefrontal loops differentially encode reward-predictive cues.bioRxiv : the preprint server for biology · 2026Article
- Communication between the medial frontal cortex and mediodorsal thalamus is required for timing performance in rats.Neurobiology of learning and memory · 2026Article
- Deconstruction the feedforward inhibition changes in the layer III of anterior cingulate cortex after peripheral nerve injury.Communications biology · 2024Article
- Causality methods to study the functional connectivity in brain networks: the basal ganglia - thalamus causal interactions.Brain imaging and behavior · 2024Article
- Influence of Recent Trial History on Interval Timing.Neuroscience bulletin · 2023Article
- Working memory control dynamics follow principles of spatial computing.Nature communications · 2023Article
- Article
- Temporal scaling and computing time in neural circuits: Should we stop watching the clock and look for its gears?Frontiers in behavioral neuroscience · 2022Article
- The Central Thalamus: Gatekeeper or Processing Hub?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Operant conditioning deficits and modified local field potential activities in parvalbumin-deficient mice.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The perception of time is critical to adaptive behavior. While prefrontal cortex and basal ganglia have been implicated in interval timing in the seconds to minutes range, little is known about the role of the mediodorsal thalamus (MD), which is a key component of the limbic cortico-basal ganglia-thalamocortical loop. In this study, we tested the role of the MD in timing, using an operant temporal production task in male mice. In this task, that the expected timing of available rewards is indicated by lever pressing. Inactivation of the MD with muscimol produced rightward shifts in peak pressing on probe trials as well as increases in peak spread, thus significantly altering both temporal accuracy and precision. Optogenetic inhibition of glutamatergic projection neurons in the MD also resulted in similar changes in timing. The observed effects were found to be independent of significant changes in movement. Our findings suggest that the MD is a critical component of the neural circuit for interval timing, without playing a direct role in regulating ongoing performance.
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