Evidence map›Paper›PMID 32493509›Full record

ArticleBMC research notes2020

Effects of bone marrow mononuclear cells on induction of axonal sprouting in cortico-cortical and cortico-striatal pathways in an animal model of cortical ablation.

Maria de Fátima Dos Santos Sampaio, Arthur Giraldi-Guimarães, Camila da Silva Lourenço, Messias Gonzaga Pereira, Norberto Cysne Coimbra

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Maria de Fátima Dos Santos SampaioLaboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av Bandeirantes 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil. mfss.sampaio@gmail.com.
Arthur Giraldi-GuimarãesLaboratory of Tissue and Cellular Biology, Centre of Biosciences and Biotechnology of Darcy Ribeiro Northern, Fluminense State University, (UENF), Av. Alberto Lamego, 2000, Campos dos Goytacazes, Rio de Janeiro, 28013-602, Brazil.
Camila da Silva LourençoLaboratory of Clinical and Surgery of Darcy Ribeiro Northern Fluminense State University (UENF), Av. Alberto Lamego, 2000, Campos dos Goytacazes, Rio de Janeiro, 28013-602, Brazil.
Messias Gonzaga PereiraLaboratory of Plant Breeding of Darcy Ribeiro Northern Fluminense State University, (UENF), Av. Alberto Lamego, 2000, Campos dos Goytacazes, Rio de Janeiro, 28013-602, Brazil.
Norberto Cysne CoimbraLaboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av Bandeirantes 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.
State University of Norte Fluminense · BRUniversidade de São Paulo · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 427397/2018-9Conselho Nacional de Desenvolvimento Científico e Tecnológico 474853/2013-6Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro grants E-26/102.179/2013Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/11855-8
6 · The paper itself

Abstract

objectivesMany therapies have been proposed in order to investigate the mechanisms of neural repair associated with neurological diseases, including bone marrow mononuclear cells (BMMC) transplantation. However, there is evidence that some encephalic injuries are less responsive to neural repair, such as, for example, cortical ablation. On the other hand, some models of cortical ablation have shown functional recovery after BMMC transplantation. Thus, it is relevant to expand the knowledge of BMMC transplantation-induced neuroplasticity in animal models, considering a promising approach for the rehabilitation of patients with neurological diseases. Using an experimental model of cerebral cortex ablation in adult male Wistar rats, which is known to be poorly responsive to neuroplasticity, the aim of this study was to investigate the effects of BMMC on axonal sprouting in cortico-cortical and cortico-striatal pathways synaptic fields. An anterograde neurotracer was used to evaluate the distribution of axonal fibres.

resultsThe results showed that BMMC were not able to significantly induce axonal sprouting in the evaluated synaptic fields. Our results reinforced the idea that cortical ablation may be less responsive to neuroplasticity and the beneficial effects of BMMC therapy depend on the particularities of a neural microenvironment intrinsic to a given cortical lesion.

Indexed as

Bone MarrowBone Marrow TransplantationCorpus StriatumAnimalsAxonsBrain InjuriesCerebral CortexDisease Models, AnimalLeukocytes, MononuclearMaleNerve RegenerationNeural PathwaysNeuroanatomical Tract-Tracing TechniquesRats, WistarBone marrow mononuclear cellsCerebral ablationCortico-cortical tractCortico-striatal tractNeocortical plasticity

Identifiers

PMID32493509
PMCPMC7271522
OpenAlexW3031180053

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.