ArticleArthritis research & therapy2020
Validation of the suction device Nimble for the assessment of skin fibrosis in systemic sclerosis.
Article in Arthritis research & therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03644225 (Mechanical Characterization of Healthy and Diseased Skin With Suction Based Assessment of Skin Deformability), which is not on this map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mechanical Characterization of Healthy and Diseased Skin With Suction Based Assessment of Skin Deformability
Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- A wearable biomechanical system for medical evaluation of soft tissue disorders.Science advances · 2026Article
- A Method to Evaluate Skin and Skin Substitute Mechanical Properties Using a Suction Device.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Near-infrared spectroscopy-enabled electromechanical systems for fast mapping of biomechanics and subcutaneous diagnosis.Science advances · 2024Article
- Comparison of treatment response measures in cutaneous sclerosis after allogeneic hematopoietic cell transplantation.Blood advances · 2024Article
- Skin mechanical properties measured with skin elasticity measurement device in patients with lymphedema: Scoping review.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- Intra- and inter-rater reliabilities of skin mechanical properties measured in healthy individuals using skin elasticity meter.Annals of medicine · 2023Article
- A quantitative comparison of devices for in vivo biomechanical characterization of human skin.Mechanics of soft materials · 2023Article
- Standardizing Dimensionless Cutometer Parameters to DetermineAdvances in wound care · 2022Article
- Longitudinal monitoring and prediction of long-term outcome of scar stiffness on pediatric patients.Burns & trauma · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesSkin fibrosis is a main hallmark of systemic sclerosis (SSc). Clinical assessment is done semi-quantitatively using the modified Rodnan skin score (mRSS). Objective measurements for quantifying skin fibrosis could complement the mRSS to achieve higher reproducibility. The aim of this study was to explore the potential of suction measurements to detect structural changes in the skin that are associated with skin fibrosis.
methodsThis clinical trial included 30 SSc patients and 30 healthy volunteers (HC). We validated a novel suction device-the Nimble-to quantify skin stiffness in comparison to the Cutometer using the OMERACT filter.
resultsA significant difference (p < 0.05) between the skin stiffness of HC and SSc patient groups was found for each location measured. The correlation between the measurements of forearm skin stiffness and the mRSS values was high for the Nimble (r = 0.82) and moderate for the Cutometer (r = 0.58). A ROC analysis showed good ability for the Nimble to distinguish between SSc patients with and without skin involvement (AUC = 0.82). Both suction devices provided excellent reliability in all measurements on HC and SSc patients and proved face validity and feasibility.
conclusionSuction devices assessing skin stiffness, such as the Nimble, show clear potential to objectively quantify skin fibrosis in SSc patients and might be promising outcome measures complementing established methods such as the mRSS.
trial registrationClinicaltrials.gov, NCT03644225, Registered 23 August 2018-Retrospectively registered, http://www.clinicaltrials.gov.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.