Evidence map›Paper›PMID 32493393›Full record

ArticleWorld journal of surgical oncology2020

Serum metabolites may be useful markers to assess vascular invasion and identify normal alpha-fetoprotein in hepatocellular carcinoma undergoing liver resection: a pilot study.

Chao-Wei Lee, Ming-Chin Yu, Gigin Lin, Jo-Chu Chiu, Meng-Han Chiang, Chang-Mu Sung, Yi-Chung Hsieh, Tony Kuo, Cheng-Yu Lin, Hsin-I Tsai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of surgical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Metabolomics in viral hepatitis: advances and review.Frontiers in cellular and infection microbiology · 2023
    Review
  7. Review
  8. Article
  9. [Research advances of metabolomics in early diagnosis of hepatocellular carcinoma].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2022
    Review
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Chao-Wei LeeDivision of General Surgery, Department of Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.ORCID http://orcid.org/0000-0002-6853-4557
Ming-Chin YuDivision of General Surgery, Department of Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Gigin LinClinical Metabolomics Core Laboratory, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Jo-Chu ChiuGraduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan.
Meng-Han ChiangClinical Metabolomics Core Laboratory, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Chang-Mu SungGraduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan.
Yi-Chung HsiehCollege of Medicine, Chang Gung University, Taoyuan, Taiwan.
Tony KuoCollege of Medicine, Chang Gung University, Taoyuan, Taiwan.
Cheng-Yu LinCollege of Medicine, Chang Gung University, Taoyuan, Taiwan.
Hsin-I TsaiGraduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan. tsaic@hotmail.com.
Chang Gung University · TWLinkou Chang Gung Memorial Hospital · TW

Funding

Chang Gung Memorial Hospital CMRPG3G0051Ministry of Science and Technology, Taiwan MOST 106-2314-B-182A-018- / NMRPG3G0181 and 107-2314-B-182A-119-/ NMRPG3H0291
6 · The paper itself

Abstract

purposeHepatocellular carcinoma (HCC) is the most common primary malignancy of the liver with a dismal prognosis. Vascular invasion, among others, is the most robust indicator of postoperative recurrence and overall survival after liver resection for HCC. Few studies to date have attempted to search for effective markers to predict vascular invasion before the operation. The current study would examine the plasma metabolic profiling via MATERIALS AND

methodsHCC patients scheduled to receive liver resections for their HCC were recruited and divided into two separate groups, investigation cohort and validation cohort. Their preoperative blood samples were collected and subjected to a comprehensive metabolomic profiling using

resultsThere were 35 HCC patients in the investigation group and 22 patients in the validation group. Chronic hepatitis B remained the most common etiology of HCC, followed by chronic HCV infection. The two study cohorts were essentially comparable in terms of major clinicopathological variables. After

conclusionA comprehensive metabolomic profiling of HCC demonstrated that serum metabolites may be utilized to assist the early diagnosis of AFP-negative HCC patients and recognition of microvascular invasion in order to facilitate preoperative surgical planning and postoperative follow-up. Further, larger scale prospective studies are warranted to consolidate our findings.

Indexed as

Agedalpha-FetoproteinsBiomarkers, TumorCarcinoma, HepatocellularFemaleHepatectomyHumansLiver NeoplasmsMaleNeoplasm InvasivenessNeoplasm Recurrence, LocalPilot ProjectsPrognosisProspective StudiesRisk FactorsROC Curvealpha-FetoproteinsBiomarkers, TumorFormateHepatocellular carcinomaHepatomaMetabolitesMetabolomicsVascular invasion

Identifiers

PMID32493393
PMCPMC7271504
OpenAlexW3031860160

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.