ArticleDiagnostic pathology2020
Yolk sac tumor differentiation in urothelial carcinoma of the urinary bladder: a case report and differential diagnosis.
Article in Diagnostic pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Primary Pure Yolk Sac Tumor of the Urinary Bladder: A Case Report.IJU case reports · 2026Article
- Extragonadal yolk sac tumor of the ureter with neuroendocrine differentiation: A case report.Urology case reports · 2026Article
- Primary adenocarcinoma with yolk sac differentiation in the transplant ureter and salvage of the transplant kidney: a rare case report.Korean journal of transplantation · 2023Article
- Urachal yolk sac tumor penetrating the bladder as a diagnostic challenge: a case report and review of the literature.Diagnostic pathology · 2022Review
- Visible haematuria-an unusual presentation of metastatic testicular mixed germ cell tumour.BMJ case reports · 2021Article
- Unusual Faces of Bladder Cancer.Cancers · 2020Review
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2 authors.
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Abstract
backgroundYolk sac tumor (YST) is a germ cell neoplasm that arises predominantly in the gonads, but can also derive from somatic neoplasms in extragonadal locations. These latter cases have been documented in several organs, although reports from the urinary tract are limited. To our knowledge, this is the first report of a bladder urothelial carcinoma with a predominant component of YST differentiation. CASE PRESENTATION: We present a unique case of a 76-year-old man with a recurrent urinary bladder tumor, initially interpreted as a high grade urothelial carcinoma with glandular differentiation. In the recurrent tumor, diverse histological patterns were identified, including glandular, hepatoid and sarcomatoid. This tumor showed positivity for AFP, GLP3 and SALL4, and negativity for CK7 and EMA. Fluorescent in situ hybridization study showed a polysomic pattern of chromosome 12. All these findings led to the final diagnosis of a YST derived from urothelial carcinoma.
conclusionsYST differentiation should be considered in the differential diagnosis of a high grade urothelial carcinoma, particularly when glandular and other unusual patterns are observed.
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