Observational studyWorld journal of surgical oncology2020
Colorectal cancer surgery in selected nonagenarians is relatively safe and it is associated with a good long-term survival: an observational study.
Observational study in World journal of surgical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Impact of Age on Surgical and Oncologic Outcomes After Colorectal Cancer Resection in Selected Patients Undergoing Primary Anastomosis: A Retrospective Propensity-Matched Cohort Study.Cancer medicine · 2026Article
- Robotic-assisted transverse colectomy for transverse colon cancer in a centenarian: a case report.Journal of surgical case reports · 2026Article
- Surgical outcomes and patient selection in nonagenarians with colon cancer: a comparative multi-institutional study of laparoscopic and open approaches.Langenbeck's archives of surgery · 2025Article
- Safety and feasibility of D3 lymph node dissection in oldest-old patients undergoing colorectal cancer surgery: a multi-institutional, retrospective analysis.Techniques in coloproctology · 2025Article
- The Perioperative NonaGEnaRIan And cenTenarian suRgICal (GERIATRIC) Risk Stratification Tool.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2024Article
- Prehabilitation in Frail Octogenarian and Nonagenarian Patients in Colorectal Cancer Surgery: Short- and Medium-Term Outcomes.Journal of clinical medicine · 2024Article
- Advancements in colorectal cancer research: Unveiling the cellular and molecular mechanisms of neddylation (Review).International journal of oncology · 2024Review
- Elective colorectal cancer surgery in nonagenarians and postoperative outcomes.Updates in surgery · 2023Article
- Colorectal cancer surgery in elderly patients 80 years and older: a comparison with younger age groups.Journal of gastrointestinal oncology · 2022Article
- Screening of ferroptosis-related genes with prognostic effect in colorectal cancer by bioinformatic analysis.Frontiers in molecular biosciences · 2022Article
- Risk scores to predict mortality 2 and 5 years after surgery for colorectal cancer in elderly patients.World journal of surgical oncology · 2021Observational
- Outcomes of colorectal cancer surgery in nonagenarian patients: a multicenter retrospective study.Journal of gastrointestinal oncology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdvanced age is a risk factor for colorectal cancer, and very elderly patients often need to be surgically treated. This study aimed to analyze the outcomes of a cohort of nonagenarian patients operated on for colorectal cancer.
methodsObservational study conducted on a cohort of 40 nonagenarian patients, who were treated surgically for colorectal cancer between 2000 and 2018 in our institution. Clinical data, ASA score, Charlson Comorbidity Index, Surgical Mortality Probability Model, tumor characteristics, and nature and technical features of the surgical procedure, were recorded. The Comprehensive Complication Index (CCI) and survival time after the procedure were recorded as outcome variables. Univariate and multivariate analyses were performed in order to define risk factors for postoperative complications and long-term survival.
resultsOut of the 40 patients, 13 (32.5%) were men, 27 (67.5%) women, and mean age 91.6 years (SD ± 1.5). In 24 patients (60%), surgery was elective, and in 16 patients (40%), surgery was emergent. Curative surgery with intestinal resection was performed in 34 patients (85%). In 22 patients (55%), intestinal continuity was restored by performing an anastomosis. The median CCI was 22.6 (IRQ 0.0-42.6). Operative mortality was 10% (4 patients). Cumulative survival at 1, 3, and 5 years was 70%, 47%, and 29%, respectively. In multivariate analysis, only the need for transfusion remained as an independent prognostic factor for complications (p = 0.021) and TNM tumor stage as a significant predictor of survival (HR 3.0, CI95% 1.3-7.2).
conclusionsColorectal cancer surgery is relatively safe in selected nonagenarian patients and may achieve long-term survival.
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