Observational studyBMC psychiatry2020
Prevalence of QTc interval prolongation and its associated risk factors among psychiatric patients: a prospective observational study.
Observational study in BMC psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Use of Electrocardiogram Monitoring in Adult Patients Taking High-Risk QT Interval Prolonging Medicines in Clinical Practice: Systematic Review and Meta-analysis.Drug safety · 2022Pooled it
- QT-prolonging antipsychotic combinations and associated risk in hospitalized patients with mental disorders in Sana'a, Yemen.Scientific reports · 2026Article
- QT interval prolongation in schizophrenia: A cross-sectional study from a tertiary care center in Raipur.The Indian journal of medical research · 2025Article
- Association of anxiolytic drugs with Torsade de Pointes: a pharmacovigilance study of the Food and Drug Administration Adverse Event Reporting System.Journal of pharmaceutical policy and practice · 2024Article
- Bipolar Disorder Among Older Adults: Newer Evidence to Guide Clinical Practice.Focus (American Psychiatric Publishing) · 2023Article
- Abnormal blood lipid and electrocardiogram characteristics in common mental disorders.BMC psychiatry · 2023Article
- Electrocardiogram abnormalities and associated factors among psychiatric patients attending follow up at Jimma Medical Center Psychiatry Clinic, Jimma, Ethiopia: an institution-based cross-sectional study.BMC cardiovascular disorders · 2023Article
- Determinants of severe QTFrontiers in psychiatry · 2023Article
- QT interval prolongation noted in one percent of 2553 Asian patients with schizophrenia: Findings from the REAP-AP survey.The Kaohsiung journal of medical sciences · 2020Article
- QT interval prolongation from antipsychotics in schizophrenia and acute psychosis - A prospective study.Industrial psychiatry journalArticle
- QTc interval in patients on psychotropic medications.Industrial psychiatry journalArticle
- Validation of a Clinical Decision Support Tool for Quantifying Risk of Torsades de Pointes in a Psychiatric Inpatient Population.Innovations in clinical neuroscienceArticle
- QTc interval changes among patients on psychotropic medications: A prospective observational study.Industrial psychiatry journalArticle
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundQT interval prolongation is a growing concern worldwide, posing psychiatric patients to life-threatening fatal arrhythmias i.e., torsade de pointes. This study aimed to identify the prevalence of QT interval prolongation, its associated risk factors and prescribing patterns of QT prolonging drugs among psychiatric patients.
methodA prospective observational study was conducted that included psychiatric patients from a tertiary care hospital and a psychiatry clinic in Peshawar, Khyber Pakhtunkhwa, Pakistan. Electrocardiogram was recorded of those patients who were using psychotropic medications for ≥7 days, aged 18 years or more, and of either gender, male or female. The Fredericia correction formula was used for measuring QTc values (corrected QT). Chi-square test was applied to estimate differences between patients with or without prolonged QTc interval whereas, logistic regression analysis was performed to identify various predictors of QT interval prolongation.
resultsOut of 405 patients, the QTc interval was prolonged in 23 (5.7%) patients including 1 (0.2%) patient with highly abnormal prolonged QTc interval (> 500 ms). QT drugs (91.6%), female sex (38.7%) and hypertension (10.6%) were the most common QT prolonging risk factors. Prolonged QTc interval was significantly higher among male patients (p = 0.007).
conclusionIn the present study, QT interval prolongation was observed in a considerable number of psychiatric patients. While, the high prevalence of QT prolonging risk factors among these patients warrants the increased risk of fatal arrhythmias. Therefore, risk assessment and electrocardiographic monitoring, and prescription of safer alternatives are highly recommended.
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