SynthesisBMC oral health2020
Clinical efficacy and the antimicrobial potential of silver formulations in arresting dental caries: a systematic review.
Synthesis in BMC oral health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Do systematic reviews of non- and micro-invasive treatment for caries lesions in children and adolescents adhere to the PRISMA reporting guidelines? A meta-research.Evidence-based dentistry · 2026Pooled it
- Antimicrobial effect of silver diamine fluoride (SDF) in arresting dentine caries of permanent teeth: A Systematic review.F1000Research · 2024Pooled it
- Antimicrobial Efficacy of Silver-based Formulations against Fusobacterium nucleatum: A Mini-scoping Review.European journal of dentistry · 2026Article
- Article
- Preparation of silver-loaded metal-organic frameworks as a novel agent for arresting dental caries of primary teeth.Scientific reports · 2025Article
- Effectiveness of biofilm-targeted therapy in managing and preventing dental caries: protocol for a systematic review and meta-analysis.Systematic reviews · 2025Article
- Cariostatic Agents: From Silver Diamine Fluoride to Emerging Bioactive Compounds.Clinical, cosmetic and investigational dentistry · 2025Review
- Mapping the Dental Applications of Nanosilver Fluoride: A Narrative Review.International journal of clinical pediatric dentistry · 2024Review
- Comparative Evaluation of the Mechanical Efficiency of Nanosilver Fluoride and Sodium Fluoride Varnish: AnInternational journal of clinical pediatric dentistry · 2024Article
- Effect of light curing on the efficacy of silver diamine fluoride: A systematic review.Journal of Taibah University Medical Sciences · 2024Review
- Biological properties of a novel solution based on silver nanoclusters for arresting dentin caries.Frontiers in oral health · 2024Article
- Smart dental materials for antimicrobial applications.Bioactive materials · 2023Article
- Effectiveness of silver diamine fluoride 38% on reduction of gingivitis in dogs: a randomized clinical trial.Frontiers in veterinary science · 2023Article
- Silver release from dentine treated with combinations of silver diamine fluoride, potassium iodide and etching.Biomaterial investigations in dentistry · 2023Article
- Fluoride and silver ion concentrations and pH in silver diamine fluoride solutions from Argentina.Acta odontologica latinoamericana : AOL · 2022Article
- Assessment of Sodium Diamine Fluoride (SDF) with Light Curing Technique: A Pilot Study of Antimicrobial Effects.Methods and protocols · 2022Article
- Application of Selected Nanomaterials and Ozone in Modern Clinical Dentistry.Nanomaterials (Basel, Switzerland) · 2021Review
- Evidence-Based Bibliometric Analysis of Research on Silver Diamine Fluoride Use in Dentistry.BioMed research international · 2021Review
- Antibacterial Activity of Silver and Its Application in Dentistry, Cardiology and Dermatology.Microorganisms · 2020Review
- Therapeutic Use of Silver Nanoparticles in the Prevention and Arrest of Dental Caries.Bioinorganic chemistry and applications · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe use of silver-formulation as microbicide to arrest dentinal caries is gaining popularity. The primary objective of the present appraisal was to systematically review the clinical (in vivo) applications and antimicrobial potential of silver-containing formulations in arresting dentinal caries. Our secondary aim was to sum up the available in vitro applications of silver-containing formulations against cariogenic microbes isolated from dentine lesions.
methodsOvid MEDLINE, EBSCO host, Web of Science, and Cochrane Library databases was searched between January 2009-May 2019.
resultsIn vivo: We observed conflicting evidence of antimicrobial efficacy of SDF on a diverse array of microbial taxa present in carious dentine of primary and permanent teeth. Moreover, there is insufficient evidence on the application of AgNP-fluoride as an effective microbicidal against cariogens of dentine lesions. In vitro: We found a good evidence of microbicidal efficacy of silver diamine fluoride (SDF) on selective cariogenic microbes in human dentine model. Additionally, a good evidence was noted of in vitro application of silver nanoparticles (AgNPs) as a useful microbicidal against S. mutans adhesion, growth and subsequent biofilm formation in human dentine models.
conclusionsTaken together, in vitro evidence indicates the promising antimicrobial potential of silver-based formulations (SDF and nanosilver) against the predominant cariogenic flora, particularly from dentine lesions. Post-treatment clinical data of either the bactericidal and bacteriostatic effects of SDF or nanosilver are sparse. Furthermore, the current understanding of the specific size, concentration, antimicrobial mechanisms, and toxicological aspects of nano-silver compounds is inadequate to draw firm conclusions on their clinical utility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.