ArticleBMC infectious diseases2020
Disseminated Talaromyces marneffei infection presenting as multiple intestinal perforations and diffuse hepatic granulomatous inflammation in an infant with STAT3 mutation: a case report.
Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Pooled it
- Characteristics of Endemic Mycoses Talaromyces marneffei Infection Associated with Inborn Errors of Immunity.Journal of clinical immunology · 2024Pooled it
- Rapid diagnosis ofFrontiers in cellular and infection microbiology · 2022Pooled it
- Human inborn errors of immunity underlyingFrontiers in immunology · 2025Article
- Disseminated Talaromyces marneffei infection initially presenting as cutaneous and subcutaneous lesion in an HIV-Negative renal transplant recipient: a case report and literature review.BMC infectious diseases · 2024Review
- Disseminated CombinedInfection and drug resistance · 2024Article
- Clinical Characteristics, Course, and Long-Term Outcomes in Patients with Talaromyces marneffei Infection: A 10-Year Retrospective Cohort Study.Infectious diseases and therapy · 2023Article
- DisseminatedOpen forum infectious diseases · 2023Article
- Talaromyces marneffei Infections in 8 Chinese Children with Inborn Errors of Immunity.Mycopathologia · 2022Article
- Article
- Characteristics and Prognosis of Talaromyces marneffei Infection in HIV-positive Children in Southern China.Mycopathologia · 2022Review
- Talaromyces marneffei infection associated with bronchiolitis obliterans in an HIV-negative child: a case report.BMC infectious diseases · 2022Article
- Anti-Interferon-γ Autoantibodies Impair T-Lymphocyte Responses in Patients withInfection and drug resistance · 2022Article
- Successful Management of Mixed Mycosis in HIV-Negative Patients With Different Immune Status: A Case Series Report.Frontiers in cellular and infection microbiology · 2022Article
- Case Report: DisseminatedFrontiers in immunology · 2021Article
- Talaromyces marneffei infection with IFNGR1 gene mutation in a patient with negative Anti-Interferon-γ autoantibodies.Anais brasileiros de dermatologiaArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundTalaromyces marneffei is a highly pathogenic fungus that can cause life-threatening fatal systemic mycosis. Disseminated Talaromycosis marneffei affects multiple organs, including the lungs, skin, and reticuloendothelial system. However, T. marneffei infection has rarely been reported in human immunodeficiency virus (HIV)-negative infants with multiple intestinal perforations and diffuse hepatic granulomatous inflammation. CASE PRESENTATION: We present the case of an HIV-negative 37-month-old boy who has had recurrent pneumonia since infancy and was infected with disseminated Talaromycosis. Contrast-enhanced computed tomography of the whole abdomen showed hepatomegaly and intestinal wall thickening in the ascending colon and cecum with mesenteric lymphadenopathy. Colonoscopy showed a cobblestone pattern with erosion, ulcer, polypoid lesions, and lumen deformation ranging from the colon to the cecum. T. marneffei was isolated from the mucous membrane of the colon, liver, and bone marrow. After antifungal treatment and surgery, his clinical symptoms significantly improved. Whole-exome sequencing using the peripheral blood of the patient and his parents' revealed a heterozygous missense mutation in exon 17 of the STAT3 gene (c.1673G>A, p.G558D).
conclusionsIn T. marneffei infection-endemic areas, endoscopic examination, culture, or histopathology from the intestine tissue should be performed in disseminated Talaromycosis patients with gastrointestinal symptoms. Timely and systemic antifungal therapy could improve the prognosis. Immunodeficiency typically should be considered in HIV-negative infants with opportunistic infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.