ArticleCirculation research2020
Long Range Endocrine Delivery of Circulating miR-210 to Endothelium Promotes Pulmonary Hypertension.
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Article in Circulation research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 38 citations in OpenAlex.
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- Exosomal miR-21 mitigates pulmonary hypertension-induced right-heart remodeling by preserves mitochondrial homeostasis.Journal of translational medicine · 2026Article
- miR-499 in Platelet-Derived Extracellular Vesicles Augments Inflammatory Cell Generation and Cardiac Remodeling After Myocardial Infarction.Circulation · 2026Article
- Sotatercept in Pulmonary Arterial Hypertension: Molecular Mechanisms, Clinical Evidence, and Emerging Role in Reverse Remodelling.International journal of molecular sciences · 2026Review
- Endothelial ADAR1 Deficit Induces the NOCT-IRF7 Axis in Pulmonary Hypertension.Circulation research · 2026Article
- Therapeutic targets for pulmonary arterial hypertension: insights into the emerging landscape.Expert opinion on therapeutic targets · 2025Review
- MicroRNA-210 Mediates Hypoxic Pulmonary Hypertension in the Newborn Lamb.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Unlocking the Potential of Extracellular Vesicles in Cardiovascular Disease.Journal of cellular and molecular medicine · 2025Review
- Pathophysiology of Group 3 Pulmonary Hypertension Associated with Lung Diseases and/or Hypoxia.International journal of molecular sciences · 2025Review
- Precision Medicine for Pulmonary Vascular Disease: The Future Is Now (2023 Grover Conference Series).Pulmonary circulation · 2025Article
- Decoding the enigmatic estrogen paradox in pulmonary hypertension: delving into estrogen metabolites and metabolic enzymes.Cellular & molecular biology letters · 2024Review
- MicroRNA-210 mediates hypoxia-induced pulmonary hypertension by targeting mitochondrial bioenergetics and mtROS flux.Acta physiologica (Oxford, England) · 2024Article
- Hypoxia-induced pulmonary hypertension in adults and newborns: implications for drug development.Drug discovery today · 2024Review
- MicroRNAs and Cardiovascular Disease Risk.Current cardiology reports · 2024Review
- CVD phenotyping in oncologic disorders: cardio-miRNAs as a potential target to improve individual outcomes in revers cardio-oncology.Journal of translational medicine · 2024Review
- Targeting Mitochondrial Metabolic Dysfunction in Pulmonary Hypertension: Toward New Therapeutic Approaches?International journal of molecular sciences · 2023Review
- Hypoxia Inhibits Cell Cycle Progression and Cell Proliferation in Brain Microvascular Endothelial Cells via the miR-212-3p/MCM2 Axis.International journal of molecular sciences · 2023Article
- miR-roring Changes in Blood: miR-210 Reflects Hypoxic Disease Dynamics in Obstructive Sleep Apnea.American journal of respiratory and critical care medicine · 2023Article
- Obstructive Sleep Apnea-induced Endothelial Dysfunction Is Mediated by miR-210.American journal of respiratory and critical care medicine · 2023Article
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Authors and funding
16 authors at 2 institutions in 2 countries.
Jingsi ZhaoCenter for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood Vascular Medicine Institute (J.Z., J.F., Y.-Y.T., L.O., T. Brzoska, Y.T., J.Y., V.N., C.-S.C.W., M.G.R., S.M.N., P.S., P.D., S.Y.C.), University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA.
Jonathan Florentin *Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood Vascular Medicine Institute (J.Z., J.F., Y.-Y.T., L.O., T. Brzoska, Y.T., J.Y., V.N., C.-S.C.W., M.G.R., S.M.N., P.S., P.D., S.Y.C.), University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA.
Yi-Yin Tai *Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood Vascular Medicine Institute (J.Z., J.F., Y.-Y.T., L.O., T. Brzoska, Y.T., J.Y., V.N., C.-S.C.W., M.G.R., S.M.N., P.S., P.D., S.Y.C.), University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA.
Stéphanie TorrinoUniversité Côte d'Azur, CNRS, IPMC, Valbonne, France (S.T., T. Bertero).
Lee OhayonCenter for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood Vascular Medicine Institute (J.Z., J.F., Y.-Y.T., L.O., T. Brzoska, Y.T., J.Y., V.N., C.-S.C.W., M.G.R., S.M.N., P.S., P.D., S.Y.C.), University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA.
Tomasz BrzoskaCenter for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood Vascular Medicine Institute (J.Z., J.F., Y.-Y.T., L.O., T. Brzoska, Y.T., J.Y., V.N., C.-S.C.W., M.G.R., S.M.N., P.S., P.D., S.Y.C.), University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA.
Ying TangCenter for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood Vascular Medicine Institute (J.Z., J.F., Y.-Y.T., L.O., T. Brzoska, Y.T., J.Y., V.N., C.-S.C.W., M.G.R., S.M.N., P.S., P.D., S.Y.C.), University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA.
Jimin YangCenter for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood Vascular Medicine Institute (J.Z., J.F., Y.-Y.T., L.O., T. Brzoska, Y.T., J.Y., V.N., C.-S.C.W., M.G.R., S.M.N., P.S., P.D., S.Y.C.), University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA.
Vinny NegiCenter for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood Vascular Medicine Institute (J.Z., J.F., Y.-Y.T., L.O., T. Brzoska, Y.T., J.Y., V.N., C.-S.C.W., M.G.R., S.M.N., P.S., P.D., S.Y.C.), University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA.
Chen-Shan Chen WoodcockCenter for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood Vascular Medicine Institute (J.Z., J.F., Y.-Y.T., L.O., T. Brzoska, Y.T., J.Y., V.N., C.-S.C.W., M.G.R., S.M.N., P.S., P.D., S.Y.C.), University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA.
Michael G RisbanoCenter for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood Vascular Medicine Institute (J.Z., J.F., Y.-Y.T., L.O., T. Brzoska, Y.T., J.Y., V.N., C.-S.C.W., M.G.R., S.M.N., P.S., P.D., S.Y.C.), University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA.
Seyed Mehdi NouraieCenter for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood Vascular Medicine Institute (J.Z., J.F., Y.-Y.T., L.O., T. Brzoska, Y.T., J.Y., V.N., C.-S.C.W., M.G.R., S.M.N., P.S., P.D., S.Y.C.), University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA.
Prithu SunddCenter for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood Vascular Medicine Institute (J.Z., J.F., Y.-Y.T., L.O., T. Brzoska, Y.T., J.Y., V.N., C.-S.C.W., M.G.R., S.M.N., P.S., P.D., S.Y.C.), University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA.
Thomas Bertero *Université Côte d'Azur, CNRS, IPMC, Valbonne, France (S.T., T. Bertero).
Partha Dutta *Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood Vascular Medicine Institute (J.Z., J.F., Y.-Y.T., L.O., T. Brzoska, Y.T., J.Y., V.N., C.-S.C.W., M.G.R., S.M.N., P.S., P.D., S.Y.C.), University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA.
Stephen Y Chan *Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood Vascular Medicine Institute (J.Z., J.F., Y.-Y.T., L.O., T. Brzoska, Y.T., J.Y., V.N., C.-S.C.W., M.G.R., S.M.N., P.S., P.D., S.Y.C.), University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA.
University of Pittsburgh · USCentre National de la Recherche Scientifique · FR
Funding
Pulmonary arteriole occlusion by platelet-neutrophil micro-emboli in Acute Chest SyndromeR01HL128297 · NHLBI · VERSITI WISCONSIN, INC. · PI SUNDD, PRITHU · 2015 to 2025
$5.4MTranslational Pulmonary Vascular BiologyT32HL110849 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sruti Shiva · 2012 to 2026
$5.0MDefining the Complex Biology of the miR-130/301 Family in Pulmonary HypertensionR01HL124021 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHAN, STEPHEN Y · 2014 to 2025
$4.9MIron-Sulfur Deficiency as a Critical Pathogenic Cause of Pulmonary HypertensionR01HL122596 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHAN, STEPHEN Y · 2015 to 2024
$4.5MSystems Biology of Diffusion Impairment in HIVR01HL140963 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BENOS, PANAGIOTIS V, CHAN, STEPHEN Y · 2018 to 2021
$3.7MMechanisms of platelet exosome-mediated acute chest syndrome in sickle cell diseaseR01HL141080 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEAL, MATTHEW D, NOVELLI, ENRICO M · 2019 to 2022
$3.1MMechanisms of Myocardial Infarction-induced insulin resistanceR01HL143967 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DUTTA, PARTHA · 2018 to 2022
$2.6MMolecular Drivers of Vascular Stiffness and Metabolic Dysfunction in HIV-Induced Pulmonary Arterial HypertensionR01HL138437 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHAN, STEPHEN Y, NORRIS, KAREN A · 2017 to 2020
$2.4MThe role of microglia Nek6 in myocardial infarction-induced cognitive impairmentR01HL142629 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DUTTA, PARTHA · 2020 to 2023
$2.3MEffect of diabetes on myelopoiesis and atherosclerosisR00HL121076 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DUTTA, PARTHA · 2016 to 2018
$732kComputational repurposing of chemotherapies for pulmonary hypertensionUH2TR002073 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHAN, STEPHEN Y · 2017 to 2018
$615kComputational repurposing of chemotherapies for pulmonary hypertensionUH3TR002073 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHAN, STEPHEN Y · 2019 to 2019
$155kAmerican Heart Association-American Stroke Association 14GRNT19600012American Heart Association-American Stroke Association 18EIA33900027NCATS NIH HHS UH2 TR002073NCATS NIH HHS UH3 TR002073NHLBI NIH HHS R00 HL121076NHLBI NIH HHS R01 HL122596NHLBI NIH HHS R01 HL124021NHLBI NIH HHS R01 HL128297NHLBI NIH HHS R01 HL138437NHLBI NIH HHS R01 HL140963NHLBI NIH HHS R01 HL141080NHLBI NIH HHS R01 HL142629NHLBI NIH HHS R01 HL143967NHLBI NIH HHS T32 HL110849
Abstract
rationaleUnproven theories abound regarding the long-range uptake and endocrine activity of extracellular blood-borne microRNAs into tissue. In pulmonary hypertension (PH), microRNA-210 (miR-210) in pulmonary endothelial cells promotes disease, but its activity as an extracellular molecule is incompletely defined.
objectiveWe investigated whether chronic and endogenous endocrine delivery of extracellular miR-210 to pulmonary vascular endothelial cells promotes PH. METHODS AND
resultsUsing
conclusionsEndogenous blood-borne transport of miR-210 into pulmonary vascular endothelial cells promotes PH, offering fundamental insight into the systemic physiology of microRNA activity. These results also describe a platform for RNA-mediated crosstalk in PH, providing an impetus for developing blood-based miR-210 technologies for diagnosis and therapy in this disease.
Indexed as
AnimalsBone Marrow TransplantationCells, CulturedCX3C Chemokine Receptor 1Disease Models, AnimalEndothelium, VascularFemaleHomeodomain ProteinsHypertension, PulmonaryHypoxiaLungMiceMice, Inbred C57BLMice, KnockoutMicroRNAsParabiosisCX3C Chemokine Receptor 1Cx3cr1 protein, mouseHomeodomain ProteinsMicroRNAsMIRN210 microRNA, mouseRAG-1 proteinendotheliumlymphocytesmacrophagemicroRNAsparabiosis
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