Evidence map›Paper›PMID 32493105›Full record

ReviewJournal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics

Cationic Emulsion-Based Artificial Tears as a Mimic of Functional Healthy Tear Film for Restoration of Ocular Surface Homeostasis in Dry Eye Disease.

Philippe Daull, Mourad Amrane, Dahlia Ismail, Georgi Georgiev, Lukasz Cwiklik, Christophe Baudouin, Andrea Leonardi, Gerhard Garhofer, Jean-Sebastien Garrigue

Open access · hybridAbstract readComparative StudyReview
In one paragraph

Review in Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 38 citations in OpenAlex.

  1. Efficacy and safety of a multi-action tear substitute based on 0.15% cross-linked hyaluronic acid, 3% trehalose and liposomes with stearylamine: A randomized, single-mask, controlled study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
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  8. Use of a Cationic Emulsion of Latanoprost to Treat Glaucoma Patients with Ocular Surface Disease: A Preclinical Review.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 5 countries.

Philippe DaullNovagali Innovation Center, Santen SAS, Evry, France.
Mourad AmraneNovagali Innovation Center, Santen SAS, Evry, France.
Dahlia IsmailNovagali Innovation Center, Santen SAS, Evry, France.
Georgi GeorgievBiointerfaces and Biomaterials Laboratory, Department of Optics and Spectroscopy, School of Optometry, Faculty of Physics, St. Kliment Ohridski University of Sofia, Sofia, Bulgaria.
Lukasz CwiklikJ. Heyrovsky Institute of Physical Chemistry, Czech Academy of Sciences, Prague, Czech Republic.
Christophe BaudouinCHNO des Quinze-Vingts, IHU FOReSIGHT, INSERM-DGOS CIC 1423, Paris, France & Sorbonne Universités, INSERM, CNRS, Institut de la Vision, Paris, France.
Andrea LeonardiDepartment of Neuroscience, Ophthalmology Unit, University of Padua, Padua, Italy.
Gerhard GarhoferDepartment of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Jean-Sebastien GarrigueNovagali Innovation Center, Santen SAS, Evry, France.
Santen (France) · FRCentre National de la Recherche Scientifique · FRCzech Academy of Sciences, J. Heyrovský Institute of Physical Chemistry · CZMedical University of Vienna · ATSofia University "St. Kliment Ohridski" · BGUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dry eye disease (DED) is a complex multifactorial disease that affects an increasing number of patients worldwide. Close to 30% of the population has experienced dry eye (DE) symptoms and presented with some signs of the disease during their lifetime. The significant heterogeneity in the medical background of patients with DEs and in their sensitivity to symptoms renders a clear understanding of DED complicated. It has become evident over the past few years that DED results from an impairment of the ocular surface homeostasis. Hence, a holistic treatment approach that concomitantly addresses the different mechanisms that result in the destabilization of the tear film (TF) and the ocular surface would be appropriate. The goal of the present review is to compile the different types of scientific evidence (from

Indexed as

AdultDry Eye SyndromesEmulsionsHealthy VolunteersHomeostasisHumansLubricant Eye DropsOcular Physiological PhenomenaSurface PropertiesTearsEmulsionsLubricant Eye Dropsartificial tearcationic emulsiondry eyepolar lipidtear film lipid layer

Identifiers

PMID32493105
PMCPMC7404832
OpenAlexW3031444696

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.