Evidence map›Paper›PMID 32492980›Full record

ArticleMicromachines2020

Fabrication of Hard-Soft Microfluidic Devices Using Hybrid 3D Printing.

Carlos Ruiz, Karteek Kadimisetty, Kun Yin, Michael G Mauk, Hui Zhao, Changchun Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Micromachines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
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  11. A Review of Microfluidic Experimental Designs for Nanoparticle Synthesis.International journal of molecular sciences · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Carlos RuizDepartment of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, 220 South 33rd St. Philadelphia, PA 19104-6315, USA.
Karteek KadimisettyDepartment of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, 220 South 33rd St. Philadelphia, PA 19104-6315, USA.
Kun YinDepartment of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, 220 South 33rd St. Philadelphia, PA 19104-6315, USA.
Michael G MaukDepartment of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, 220 South 33rd St. Philadelphia, PA 19104-6315, USA.
Hui ZhaoDepartment of Mechanical Engineering, University of Nevada, Las Vegas, NV 89154, USA.
Changchun LiuDepartment of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, 220 South 33rd St. Philadelphia, PA 19104-6315, USA.

Funding

Asymmetric CRISPR Approach for Nucleic Acid QuantificationR01EB023607 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Changchun Liu · 2017 to 2026
$2.4M
Point of Care Diagnostics of HPV-Associated Cervical Cancer in HIV Epidemic Areas in ChinaR01CA214072 · NCI · UNIVERSITY OF PENNSYLVANIA · PI LIU, CHANGCHUN · 2017 to 2021
$771k
NCI NIH HHS R01CA214072NIBIB NIH HHS R01EB023607USDA National Institute of Food and Agriculture 2016-08811
6 · The paper itself

Abstract

Widely accessible, inexpensive, easy-to-use consumer 3D printers, such as desktop stereolithography (SLA) and fused-deposition modeling (FDM) systems are increasingly employed in prototyping and customizing miniaturized fluidic systems for diagnostics and research. However, these 3D printers are generally limited to printing parts made of only one material type, which limits the functionality of the microfluidic devices without additional assembly and bonding steps. Moreover, mating of different materials requires good sealing in such microfluidic devices. Here, we report methods to print hybrid structures comprising a hard, rigid component (clear polymethacrylate polymer) printed by a low-cost SLA printer, and where the first printed part is accurately mated and adhered to a second, soft, flexible component (thermoplastic polyurethane elastomer) printed by an FDM printer. The prescribed mounting and alignment of the first-printed SLA-printed hard component, and its pre-treatment and heating during the second FDM step, can produce leak-free bonds at material interfaces. To demonstrate the utility of such hybrid 3D-printing, we prototype and test three components: i) finger-actuated pump, ii) quick-connect fluid coupler, and iii) nucleic acid amplification test device with screw-type twist sealing for sample introduction.

Indexed as

3D-printingmicrofluidicsnucleic acid amplification testpoint-of-care diagnosticsprototyping

Identifiers

PMID32492980
PMCPMC7345326

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.