Evidence map›Paper›PMID 32492789›Full record

SynthesisMarine drugs2020

Effect of Omega-3 Polyunsaturated Fatty Acids Treatment on Lipid Pattern of HIV Patients: A Meta-Analysis of Randomized Clinical Trials.

Federica Fogacci, Enrico Strocchi, Maddalena Veronesi, Claudio Borghi, Arrigo F G Cicero

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Marine drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Residual Traditional Risk in Non-Traditional Atherosclerotic Diseases.International journal of molecular sciences · 2025
    Review
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Federica FogacciAtherosclerosis and Hypertension Research Group, Medical and Surgical Sciences Department, Sant'Orsola-Malpighi University Hospital, Building 2-IV Floor, Via Albertoni 15, 40138 Bologna, Italy.ORCID 0000-0001-7853-0042
Enrico StrocchiAtherosclerosis and Hypertension Research Group, Medical and Surgical Sciences Department, Sant'Orsola-Malpighi University Hospital, Building 2-IV Floor, Via Albertoni 15, 40138 Bologna, Italy.
Maddalena VeronesiAtherosclerosis and Hypertension Research Group, Medical and Surgical Sciences Department, Sant'Orsola-Malpighi University Hospital, Building 2-IV Floor, Via Albertoni 15, 40138 Bologna, Italy.
Claudio BorghiAtherosclerosis and Hypertension Research Group, Medical and Surgical Sciences Department, Sant'Orsola-Malpighi University Hospital, Building 2-IV Floor, Via Albertoni 15, 40138 Bologna, Italy.
Arrigo F G CiceroAtherosclerosis and Hypertension Research Group, Medical and Surgical Sciences Department, Sant'Orsola-Malpighi University Hospital, Building 2-IV Floor, Via Albertoni 15, 40138 Bologna, Italy.ORCID 0000-0002-4367-3884

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Even though omega-3 polyunsaturated fatty acids (PUFAs) seem to be effective in the treatment of human immunodeficiency virus (HIV)-associated dyslipidemia, their impact is still debated. For this reason, our aim was to perform a meta-analysis of the clinical evidence available to date. A systematic literature search was conducted in order to identify published clinical trials assessing the effect of PUFAs treatment on serum lipoproteins, and its safety profile. The effect sizes for lipid changes were expressed as mean difference (MD) and 95% confidence interval (CI). For safety analysis, odd ratios and the 95% CI were calculated with the Mantel-Haenszel method. Data were pooled from nine clinical studies comprising overall 578 HIV-affected subjects. Meta-analysis of the data suggested that omega-3 PUFAs significantly reduced triglycerides (TG) (MD = -1.04, 95% CI: -1.5, -0.58 mmol/L,

Indexed as

AdultCardiovascular DiseasesCholesterol, HDLCholesterol, LDLDyslipidemiasEicosapentaenoic AcidFatty Acids, Omega-3FemaleHIV InfectionsHumansMaleMiddle AgedRandomized Controlled Trials as TopicTriglyceridesCholesterol, HDLCholesterol, LDLEicosapentaenoic AcidFatty Acids, Omega-3Triglycerideshigh-density lipoprotein cholesterolHIVmeta-analysisOmega-3 polyunsaturated fatty acidstriglycerides

Identifiers

PMID32492789
PMCPMC7345035

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.