ArticleCell2020
Neuronal Inactivity Co-opts LTP Machinery to Drive Potassium Channel Splicing and Homeostatic Spike Widening.
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Article in Cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
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Who cites it
46 citing papers in PubMed, 72 citations in OpenAlex.
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- RNA targeting therapy for a prenatally enriched potassium channel associated with severe childhood epilepsy and premature death.Nature communications · 2026Article
- Homeostatic preservation of action potential waveform by Notch and Nerfin-1.Current biology : CB · 2026Article
- Metabolic interactions in the brain: the crucial roles of neurons, astrocytes, and microglia in health and disease.Frontiers in neuroscience · 2026Review
- Modular arrangement of synaptic and intrinsic homeostatic plasticity within visual cortical circuits.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
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- CaMK modulates sensory neural activity to control longevity and proteostasis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Homeostatic regulation of a motor circuit through temperature sensing rather than activity sensing.Current biology : CB · 2025Article
- Unreliable homeostatic action potential broadening in cultured dissociated neurons.bioRxiv : the preprint server for biology · 2025Article
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- Altered synaptic homeostasis: a key factor in the pathophysiology of depression.Cell & bioscience · 2025Review
- Modular Arrangement of Synaptic and Intrinsic Homeostatic Plasticity within Visual Cortical Circuits.bioRxiv : the preprint server for biology · 2025Article
- A fast and responsive voltage indicator with enhanced sensitivity for unitary synaptic events.Neuron · 2024Article
- Neural Influences on Tumor Progression Within the Central Nervous System.CNS neuroscience & therapeutics · 2024Review
- Epigenetic control of adaptive or homeostatic splicing during interval-training activities.Nucleic acids research · 2024Article
- A Self-Oscillated Organic Synapse for In-Memory Two-Factor Authentication.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding.Nature neuroscience · 2024Article
- Synaptic homeostasis transiently leverages Hebbian mechanisms for a multiphasic response to inactivity.Cell reports · 2024Article
- Multiomics of early epileptogenesis in mice reveals phosphorylation and dephosphorylation-directed growth and synaptic weakening.iScience · 2024Article
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Authors and funding
16 authors at 6 institutions in 2 countries.
Boxing LiNeuroscience Program, Guangdong Provincial Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine and The Fifth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510810, China; Department of Neuroscience and Physiology, Neuroscience Institute, NYU Grossman Medical Center, New York, NY 10016, USA. Electronic address: liboxing@mail.sysu.edu.cn.
Benjamin S SuutariDepartment of Neuroscience and Physiology, Neuroscience Institute, NYU Grossman Medical Center, New York, NY 10016, USA; Center for Neural Science, New York University, New York, NY 10003, USA.
Simón(e) D. SunDepartment of Neuroscience and Physiology, Neuroscience Institute, NYU Grossman Medical Center, New York, NY 10016, USA; Center for Neural Science, New York University, New York, NY 10003, USA.
Zhengyi LuoGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, RNA Biomedical Institute, Sun Yat-sen Memorial Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510120, China.
Chuanchuan WeiNeuroscience Program, Guangdong Provincial Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine and The Fifth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510810, China.
Nicolas ChenouardDepartment of Neuroscience and Physiology, Neuroscience Institute, NYU Grossman Medical Center, New York, NY 10016, USA.
Nataniel J MandelbergDepartment of Neuroscience and Physiology, Neuroscience Institute, NYU Grossman Medical Center, New York, NY 10016, USA.
Guoan ZhangDepartment of Biochemistry and Molecular Pharmacology and Skirball Institute, NYU Grossman Medical Center, New York, NY 10016, USA.
Brie WamsleyDepartment of Neuroscience and Physiology, Neuroscience Institute, NYU Grossman Medical Center, New York, NY 10016, USA; Stanley Center for Psychiatric Research, The Broad Institute, Cambridge, MA 02142, USA.
Guoling TianDepartment of Neuroscience and Physiology, Neuroscience Institute, NYU Grossman Medical Center, New York, NY 10016, USA.
Sandrine SanchezDepartment of Neuroscience and Physiology, Neuroscience Institute, NYU Grossman Medical Center, New York, NY 10016, USA.
Sikun YouNeuroscience Program, Guangdong Provincial Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine and The Fifth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510810, China.
Lianyan HuangNeuroscience Program, Guangdong Provincial Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine and The Fifth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510810, China.
Thomas A NeubertDepartment of Biochemistry and Molecular Pharmacology and Skirball Institute, NYU Grossman Medical Center, New York, NY 10016, USA.
Gordon FishellDepartment of Neuroscience and Physiology, Neuroscience Institute, NYU Grossman Medical Center, New York, NY 10016, USA; Stanley Center for Psychiatric Research, The Broad Institute, Cambridge, MA 02142, USA.
Richard W TsienDepartment of Neuroscience and Physiology, Neuroscience Institute, NYU Grossman Medical Center, New York, NY 10016, USA; Center for Neural Science, New York University, New York, NY 10003, USA. Electronic address: richard.tsien@nyulangone.org.
Neurosciences Institute · USNew York University · USSun Yat-sen University · CNBroad Institute · USFifth Affiliated Hospital of Sun Yat-sen University · CNSun Yat-sen Memorial Hospital · CN
Funding
Neuronal Adaptation and Plasticity after Chronic DisuseR01MH071739 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TSIEN, RICHARD W · 2015 to 2024
$5.5MNEURONAL FUNCTIONS OF MULTIPLE TYPES OF CALCIUM CHANNELSR01NS024067 · NINDS · YALE UNIVERSITY · PI TSIEN, RICHARD W · 1986 to 2014
$5.0MSynaptic Adaptation and Plasticity After Chronic DisuseR37MH071739 · NIMH · STANFORD UNIVERSITY · PI TSIEN, RICHARD W · 2004 to 2013
$3.8MCALCIUM CHANNELS, CALMODULIN AND NUCLEAR CREB SIGNALINGR01GM058234 · NIGMS · STANFORD UNIVERSITY · PI TSIEN, RICHARD W · 1998 to 2010
$3.0MCalcium Channels, Calmodulin and Nuclear CREB SignalingR01DA040484 · NIDA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TSIEN, RICHARD W · 2015 to 2019
$2.0MNIDA NIH HHS R01 DA040484NIGMS NIH HHS R01 GM058234NIMH NIH HHS R01 MH071739NIMH NIH HHS R37 MH071739NINDS NIH HHS R01 NS024067
Abstract
Homeostasis of neural firing properties is important in stabilizing neuronal circuitry, but how such plasticity might depend on alternative splicing is not known. Here we report that chronic inactivity homeostatically increases action potential duration by changing alternative splicing of BK channels; this requires nuclear export of the splicing factor Nova-2. Inactivity and Nova-2 relocation were connected by a novel synapto-nuclear signaling pathway that surprisingly invoked mechanisms akin to Hebbian plasticity: Ca
Indexed as
Action PotentialsAlternative SplicingAnimalsCalcium-Calmodulin-Dependent Protein KinasesCalcium-Calmodulin-Dependent Protein Kinase Type 1FemaleHEK293 CellsHomeostasisHumansLarge-Conductance Calcium-Activated Potassium ChannelsLong-Term PotentiationMaleMiceMice, Inbred C57BLNerve Tissue ProteinsNeuronal PlasticityCalcium-Calmodulin-Dependent Protein KinasesCalcium-Calmodulin-Dependent Protein Kinase Type 1Large-Conductance Calcium-Activated Potassium ChannelsNerve Tissue ProteinsNeuro-Oncological Ventral AntigenNOVA2 protein, humanRNA-Binding Proteinsaction potential durationAlternative splicingBK channelCaM kinasechronic inactivityhomeostasisNova-2synaptic activity
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