Evidence map›Paper›PMID 32492251›Full record

SynthesisPediatric pulmonology2020

Clinical manifestations of children with COVID-19: A systematic review.

Tiago H de Souza, José A Nadal, Roberto J N Nogueira, Ricardo M Pereira, Marcelo B Brandão

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Pediatric pulmonology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 166 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
166citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

166 citing papers in PubMed, 11 syntheses or guidelines pooled it.

  1. Pooled it
  2. The role of children in household transmission of COVID-19: a systematic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
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  8. Risk and protective factors of SARS-CoV-2 infection.Journal of medical virology · 2021
    Pooled it
  9. Guideline
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  20. COVID-19 in Children and Vitamin D.International journal of molecular sciences · 2024
    Review

106 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tiago H de SouzaPediatric Intensive Care Unit, Department of Pediatrics, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-6944-0221
José A NadalPediatric Intensive Care Unit, Department of Pediatrics, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Roberto J N NogueiraPediatric Intensive Care Unit, Department of Pediatrics, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Ricardo M PereiraPediatric Intensive Care Unit, Department of Pediatrics, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Marcelo B BrandãoPediatric Intensive Care Unit, Department of Pediatrics, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe coronavirus disease 2019 (COVID-19) outbreak is an unprecedented global public health challenge, leading to thousands of deaths every day worldwide. Despite the epidemiological importance, clinical patterns of children with COVID-19 remain unclear. The aim of this study was to describe the clinical, laboratorial, and radiological characteristics of children with COVID-19.

methodsThe Medline database was searched between December 1st 2019 and April 6th 2020. No language restrictions were applied. Inclusion criteria were (a) studied patients younger than 18 years old; (b) presented original data from cases of COVID-19 confirmed by reverse-transcription polymerase chain reaction; and (c) contained descriptions of clinical manifestations, laboratory tests, or radiological examinations.

resultsA total of 38 studies (1124 cases) were included. From all the cases, 1117 had their severity classified: 14.2% were asymptomatic, 36.3% were mild, 46.0% were moderate, 2.1% were severe, and 1.2% were critical. The most prevalent symptom was fever (47.5%), followed by cough (41.5%), nasal symptoms (11.2%), diarrhea (8.1%), and nausea/vomiting (7.1%). One hundred forty-five (36.9%) children were diagnosed with pneumonia and 43 (10.9%) upper airway infections were reported. Reduced lymphocyte count was reported in 12.9% of cases. Abnormalities in computed tomography were reported in 63.0% of cases. The most prevalent abnormalities reported were ground-glass opacities, patchy shadows, and consolidations. Only one death was reported.

conclusionsClinical manifestations of children with COVID-19 differ widely from adult cases. Fever and respiratory symptoms should not be considered a hallmark of COVID-19 in children.

Indexed as

AdolescentBetacoronavirusChildChild, PreschoolClinical Laboratory TechniquesCoronavirus InfectionsCoughCOVID-19COVID-19 TestingErythemaFemaleFeverHumansInfantInfant, NewbornMalechildrencoronavirusCOVID-19SARS-CoV-2

Identifiers

PMID32492251
PMCPMC7300659

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.