ArticleInvestigative ophthalmology & visual science2020
Association Between Alterations of the Choriocapillaris Microcirculation and Visual Function and Cone Photoreceptors in Patients With Diabetes.
Article in Investigative ophthalmology & visual science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Two-year prospective natural history study of EYS-associated retinitis pigmentosa using adaptive optics: the KEYS study.Scientific reports · 2026Observational
- Retinal and Choriocapillaris Thickness Changes in Spontaneously Diabetic Macaques.Investigative ophthalmology & visual science · 2025Article
- The role of optical coherence tomography angiography in assessing diabetic choroidopathy: a systematic review.International journal of retina and vitreous · 2025Review
- Metabolic, Microvascular, and Structural Predictors of Long-Term Functional Changes Evaluated by Multifocal Electroretinogram in Type 1 Diabetes.Biomedicines · 2024Article
- Diabetes Renders Photoreceptors Susceptible to Retinal Ischemia-Reperfusion Injury.Investigative ophthalmology & visual science · 2024Article
- Photoreceptor Characteristics in Diabetic Retinopathy vs Controls Using Adaptive Optics Imaging: Systematic Review.Journal of vitreoretinal diseases · 2024Review
- Association between choroidopathy and photoreceptors during the early stage of diabetic retinopathy: a cross-sectional study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Retinal Photoreceptors and Microvascular Changes in the Assessment of Diabetic Retinopathy Progression: A Two-Year Follow-Up Study.Diagnostics (Basel, Switzerland) · 2023Article
- The Role of Diabetic Choroidopathy in the Pathogenesis and Progression of Diabetic Retinopathy.International journal of molecular sciences · 2023Review
- Article
- Progression Biomarkers of Microvascular and Photoreceptor Changes Upon Long-Term Evaluation in Type 1 Diabetes.Investigative ophthalmology & visual science · 2023Article
- Assessment of Detailed Photoreceptor Structure and Retinal Sensitivity in Diabetic Macular Ischemia Using Adaptive Optics-OCT and Microperimetry.Investigative ophthalmology & visual science · 2021Article
- Correlation Between Choriocapillaris Density and Retinal Sensitivity in Age-Related Macular Degeneration.Translational vision science & technology · 2021Article
- Macular Microvasculature and Associated Retinal Layer Thickness in Pediatric Amblyopia: Magnification-Corrected Analyses.Investigative ophthalmology & visual science · 2021Article
- Long-Term Retinal Neurovascular and Choroidal Changes After Panretinal Photocoagulation in Diabetic Retinopathy.Frontiers in medicine · 2021Article
- Optimizing 3D retinal vasculature imaging in diabetic retinopathy using registration and averaging of OCT-A.Biomedical optics express · 2021Article
- Adaptive Optics Imaging in Diabetic Retinopathy: A Comprehensive Review.Romanian journal of ophthalmologyReview
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The purpose of this study was to investigate the association between the choriocapillaris microcirculation and the visual function and cone photoreceptor structure in patients with diabetes. Methods: Thirteen control subjects and 26 patients with type 2 diabetes were recruited. The patients with diabetes were divided into three groups based on the grade of diabetic retinopathy (DR). The retinal sensitivity (RS) was evaluated using microperimetry. Cone photoreceptor mosaics were imaged using an adaptive optics retinal camera, and the cone heterogeneity packing index (HPi) was calculated. Optical coherence tomography angiography (OCTA) images of the choriocapillaris were obtained using spectral-domain OCTA, and the area of flow deficit (FD) was evaluated. All parameters were evaluated in the foveal and parafoveal areas. Results: The study included four patients with diabetes without retinopathy, 12 patients with nonproliferative diabetic retinopathy (NPDR), and 10 patients with proliferative diabetic retinopathy (PDR). The foveal and parafoveal FDs were correlated significantly (fovea, r = -0.58; P = 0.046 and r = -0.82; P = 0.003; parafovea, r = -0.59; P = 0.044 and r = -0.72; and P = 0.019, respectively) with the RS in patients with NPDR and PDR, but not in control and no diabetic retinopathy (NDR) groups. There were no differences in the foveal HPi among the groups. Conclusions: Impaired choriocapillaris microcirculation is associated with impaired visual function but not cone photoreceptor integrity in eyes with DR.
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