Evidence map›Paper›PMID 32491985›Full record

ArticleeLife2020

A conserved RNA degradation complex required for spreading and epigenetic inheritance of heterochromatin.

Gergana Shipkovenska, Alexander Durango, Marian Kalocsay, Steven P Gygi, Danesh Moazed

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 49 citations in OpenAlex.

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  14. Specialized replication of heterochromatin domains ensures self-templated chromatin assembly and epigenetic inheritance.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  15. Review
  16. Minimal requirements for the epigenetic inheritance of engineered silent chromatin domains.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Gergana ShipkovenskaHoward Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, United States.ORCID 0000-0001-6288-4401
Alexander DurangoHoward Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, United States.
Marian KalocsayDepartment of Cell Biology, Harvard Medical School, Boston, United States.
Steven P GygiDepartment of Cell Biology, Harvard Medical School, Boston, United States.
Danesh MoazedHoward Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, United States.ORCID 0000-0003-0321-6221
Howard Hughes Medical Institute · USHarvard University · US

Funding

RNAi-mediated Targeting of Hetorochromatin AssemblyR01GM072805 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MOAZED, DANESH · 2005 to 2025
$6.9M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM072805NIH HHS RO1 GM072805
6 · The paper itself

Abstract

Heterochromatic domains containing histone H3 lysine 9 methylation (H3K9me) can be epigenetically inherited independently of underlying DNA sequence. To gain insight into the mechanisms that mediate epigenetic inheritance, we used a

Indexed as

HeterochromatinConserved SequenceEpigenesis, GeneticHistonesHumansMethylationRNA, FungalRNA StabilitySchizosaccharomycesSchizosaccharomyces pombe ProteinsHeterochromatinHistonesRNA, FungalSchizosaccharomyces pombe Proteinscell biologychromosomesepigeneticsgene expressionH3K9 methylationheterochromatinRix1rixosomeRNA degradationS. pombe

Identifiers

PMID32491985
PMCPMC7269676
OpenAlexW3028861603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.