ArticleAmerican journal of physiology. Lung cellular and molecular physiology2020
Protein tyrosine phosphatase-α amplifies transforming growth factor-β-dependent profibrotic signaling in lung fibroblasts.
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Article in American journal of physiology. Lung cellular and molecular physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
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Who cites it
12 citing papers in PubMed, 13 citations in OpenAlex.
- WuYeLuGen Granule Attenuates Bleomycin-Induced Pulmonary Fibrosis in Rats by Inhibiting the TGF-β1/Smad Signaling Pathway and Epithelial-Mesenchymal Transition.Canadian respiratory journal · 2026Article
- Deciphering the interplay: circulating cell-free DNA, signaling pathways, and disease progression in idiopathic pulmonary fibrosis.3 Biotech · 2025Review
- Examining the contribution of Notch signaling to lung disease development.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Article
- Clustering of phosphatase RPTPα promotes Src signaling and the arthritogenic action of synovial fibroblasts.Science signaling · 2023Article
- Targeting protein phosphatases in cancer immunotherapy and autoimmune disorders.Nature reviews. Drug discovery · 2023Review
- Pediatric adenovirus pneumonia: clinical practice and current treatment.Frontiers in medicine · 2023Review
- Saracatinib, a Selective Src Kinase Inhibitor, Blocks Fibrotic Responses in Preclinical Models of Pulmonary Fibrosis.American journal of respiratory and critical care medicine · 2022Article
- PTPα promotes fibroproliferative responses after acute lung injury.American journal of physiology. Lung cellular and molecular physiology · 2022Article
- ACPA Alleviates Bleomycin-Induced Pulmonary Fibrosis by Inhibiting TGF-β-Smad2/3 Signaling-Mediated Lung Fibroblast Activation.Frontiers in pharmacology · 2022Article
- Article
- Pulmonary fibrosis: something old, something new…still waiting for a breakthrough.American journal of physiology. Lung cellular and molecular physiology · 2020Article
Corrections and comments
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Authors and funding
21 authors at 5 institutions in 3 countries.
Yael AschnerDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, Aurora, Colorado.
Meghan NelsonDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado.
Matthew BrennerDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado.
Helen RoybalDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado.
Keriann BekeDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado.
Carly MeadorDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado.
Daniel FosterDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado.
Kelly A CorrellDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado.
Paul R ReynoldsDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado.
Kelsey AndersonCenter for Genes, Environment, and Health, National Jewish Health, Denver, Colorado.
Elizabeth F RedenteDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, Aurora, Colorado.
Jennifer MatsudaDepartment of Biomedical Research, National Jewish Health, Denver, Colorado.
David W H RichesDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, Aurora, Colorado.ORCID 0000-0002-9587-3335
Steve D GroshongDivision of Pathology, Department of Medicine, National Jewish Health, Denver, Colorado.
Ambra PozziDivision of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
Jan SapEpigenetics and Cell Fate, Université Paris, Paris, France.
Qin WangMatrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.
Dhaarmini RajshankarMatrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.
Christopher A G McCullochMatrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.
Rachel L ZemansDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Gregory P DowneyDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, Aurora, Colorado.
National Jewish Health · USUniversity of Toronto · CAEpigénétique et Destin Cellulaire · FRUniversity of Michigan · USVanderbilt University · US
Funding
Vanderbilt O'Brien Kidney Center - Core D - Clinical and Translational CoreP30DK114809 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DE CAESTECKER, MARK P. · 2017 to 2021
$5.9MInstitutional Career Development CoreKL2TR002534 · NCATS · UNIVERSITY OF COLORADO DENVER · PI BURNHAM, ELLEN L · 2018 to 2022
$4.6MProteolysis in the Pathogenesis of ARDSR01HL157424 · NHLBI · NATIONAL JEWISH HEALTH · PI DOWNEY, GREGORY PAUL, RADISKY, DEREK C · 2022 to 2025
$2.8MFibroblast Resistance to Apoptosis in Pulmonary FibrosisR01HL140595 · NHLBI · NATIONAL JEWISH HEALTH · PI RICHES, DAVID W. · 2018 to 2021
$2.5MCheckpoint Function of PTPalpha in Pathological Fibrogenesis in the LungR01HL132950 · NHLBI · NATIONAL JEWISH HEALTH · PI DOWNEY, GREGORY PAUL · 2016 to 2019
$2.0MMechanisms of Repair of the Alveolar Epithelium after Lung InjuryR01HL131608 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZEMANS, RACHEL LYNNE · 2016 to 2020
$1.9MMatrix receptors in chronic kidney diseaseR01DK119212 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BORZA, CORINA MARILENA, POZZI, AMBRA · 2018 to 2022
$1.7MDUSP1 as a therapeutic target in fibroproliferative acute lung injuryR01HL114754 · NHLBI · NATIONAL JEWISH HEALTH · PI RICHES, DAVID W. · 2013 to 2016
$1.6MRole of TGFβ/BMP Antagonism in Regeneration of the Alveolar Epithelium After Lung InjuryR01HL147920 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZEMANS, RACHEL LYNNE · 2020 to 2021
$992kPhosphorylation Control of Fibroproliferative ARDSK08HL135279 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ASCHNER, YAEL · 2019 to 2023
$810kRole of Beta-catenin in Epithelial Repair in Acute Lung InjuryK08HL103772 · NHLBI · NATIONAL JEWISH HEALTH · PI ZEMANS, RACHEL LYNNE · 2010 to 2014
$626kTargeting PTPalpha to Prevent Lung FibrosisR21ES023932 · NIEHS · NATIONAL JEWISH HEALTH · PI DOWNEY, GREGORY PAUL · 2014 to 2015
$436kBLRD VA I01 BX000320BLRD VA I01 BX002025BLRD VA I01 BX003471BLRD VA IK2 BX002401BLRD VA IK6 BX005240NCATS NIH HHS KL2 TR002534NHLBI NIH HHS K08 HL103772NHLBI NIH HHS K08 HL135279NHLBI NIH HHS R01 HL131608NHLBI NIH HHS R01 HL132950NHLBI NIH HHS R01 HL140595NHLBI NIH HHS R01 HL147920NHLBI NIH HHS R01 HL157424NIDDK NIH HHS P30 DK114809NIDDK NIH HHS R01 DK119212NIEHS NIH HHS R21 ES023932VA BX002401VA I01BX003471
Abstract
Idiopathic pulmonary fibrosis (IPF) is a progressive, often fatal, fibrosing lung disease for which treatment remains suboptimal. Fibrogenic cytokines, including transforming growth factor-β (TGF-β), are central to its pathogenesis. Protein tyrosine phosphatase-α (PTPα) has emerged as a key regulator of fibrogenic signaling in fibroblasts. We have reported that mice globally deficient in PTPα (
Indexed as
AnimalsBleomycinCells, CulturedEpithelial CellsFibroblastsIdiopathic Pulmonary FibrosisLungMiceMice, Inbred C57BLPhosphorylationReceptor-Like Protein Tyrosine Phosphatases, Class 4Signal TransductionTransforming Growth Factor betaBleomycinPtpra protein, mouseReceptor-Like Protein Tyrosine Phosphatases, Class 4Transforming Growth Factor betafibroblastIPFprotein tyrosine phosphatase-αpulmonary fibrosisTGF-β
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.