Evidence map›Paper›PMID 32491837›Full record

ArticleACS chemical biology2020

Substrate Plasticity of a Fungal Peptide α-

Haigang Song, Ju Ratè Fahrig-Kamarauskaitè, Emmanuel Matabaro, Hannelore Kaspar, Sally L Shirran, Christina Zach, Amy Pace, Bozhidar-Adrian Stefanov, James H Naismith, Markus Künzler

Open access · hybridAbstract read
In one paragraph

Article in ACS chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Diverse Protein Architectures and α-ACS chemical biology · 2022
    Article
  10. Engineering of a Peptide α-N-Methyltransferase to Methylate Non-Proteinogenic Amino Acids.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2021
    Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Haigang SongDivision of Structural Biology, Wellcome Trust Centre of Human Genomics, Roosevelt Drive, Oxford OX3 7BN, United Kingdom.ORCID 0000-0002-7568-0544
Ju Ratè Fahrig-KamarauskaitèInstitute of Microbiology, Department of Biology, Eidgenössische Technische Hochschule (ETH) Zürich, Zürich, Switzerland.
Emmanuel MatabaroInstitute of Microbiology, Department of Biology, Eidgenössische Technische Hochschule (ETH) Zürich, Zürich, Switzerland.
Hannelore KasparInstitute of Microbiology, Department of Biology, Eidgenössische Technische Hochschule (ETH) Zürich, Zürich, Switzerland.
Sally L ShirranBiomedical Sciences Research Complex, North Haugh, University of St. Andrews, Fife KY16 9ST, United Kingdom.
Christina ZachInstitute of Microbiology, Department of Biology, Eidgenössische Technische Hochschule (ETH) Zürich, Zürich, Switzerland.
Amy PaceInstitute of Microbiology, Department of Biology, Eidgenössische Technische Hochschule (ETH) Zürich, Zürich, Switzerland.
Bozhidar-Adrian StefanovInstitute of Microbiology, Department of Biology, Eidgenössische Technische Hochschule (ETH) Zürich, Zürich, Switzerland.
James H NaismithDivision of Structural Biology, Wellcome Trust Centre of Human Genomics, Roosevelt Drive, Oxford OX3 7BN, United Kingdom.ORCID 0000-0001-6744-5061
Markus KünzlerInstitute of Microbiology, Department of Biology, Eidgenössische Technische Hochschule (ETH) Zürich, Zürich, Switzerland.ORCID 0000-0003-1275-0629
Board of the Swiss Federal Institutes of Technology · CHCentre for Human Genetics · GBUniversity of St Andrews · GB

Funding

Biotechnology and Biological Sciences Research Council BB/R018189/1Wellcome Trust 094476/Z/10/Z
6 · The paper itself

Abstract

The methylation of amide nitrogen atoms can improve the stability, oral availability, and cell permeability of peptide therapeutics. Chemical

Indexed as

AgaricalesAmino Acid SequenceFungal ProteinsMethylationMethyltransferasesMutationPeptides, CyclicProtein DomainsProtein PrecursorsProtein Processing, Post-TranslationalSubstrate SpecificityFungal ProteinsMethyltransferasesomphalotin APeptides, CyclicProtein Precursors

Identifiers

PMID32491837
PMCPMC7372559
OpenAlexW3029058133

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.