ReviewRevista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
How can we improve antidepressant adherence in the management of depression? A targeted review and 10 clinical recommendations.
Review in Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A bitter pill to swallow? Impact of affective temperaments on treatment adherence: a systematic review and meta-analysis.Translational psychiatry · 2022Pooled it
- Prevalence of depression and anxiety among children with type 1 and type 2 diabetes: a systematic review and meta-analysis.World journal of pediatrics : WJP · 2022Pooled it
- Trajectories of antidepressant dispensing among privately insured transgender people in the United States.Scientific reports · 2026Article
- Understanding Adherence to Duloxetine in Psychiatric Practice: A Cross-Sectional Evaluation of Clinicians' Experience.Brain sciences · 2026Article
- Study protocol for a pilot randomized controlled trial on the feasibility and preliminary efficacy of an integrated psychoeducational intervention for transition-age youths in acute psychiatric settings.Frontiers in psychiatry · 2026Article
- Sciatic Nerve Stimulation Mitigates Depression-Like Behaviors and Memory Deficits in Stressed Mice.The Kaohsiung journal of medical sciences · 2026Article
- Patterns of antidepressant treatment changes among adults with major depressive disorder in Northwest Ethiopia: a hospital-based cross-sectional study.Therapeutic advances in psychopharmacology · 2026Article
- Article
- Impact of pharmaceutical care interventions on antidepressants adherence and clinical outcomes in depressed patients: A systematic review.Exploratory research in clinical and social pharmacy · 2025Review
- Depression, antidepressant use, and breast cancer incidence: results from the E3N prospective cohort.Psychiatry and clinical neurosciences · 2025Article
- Article
- Trajectories of antidepressant use after tamoxifen initiation among young and middle-aged women with breast cancer.Breast cancer research and treatment · 2025Article
- Investigating Remedial Strategies for Missed or Delayed Dose of Sertraline in Chinese Adolescent Patients with Depressive Disorders via Population Pharmacokinetics Modeling and Simulation Approaches.Drug design, development and therapy · 2025Article
- Types of Medication Non-adherence & Approaches to Enhance Medication Adherence in Mental Health Disorders: A Narrative Review.Indian journal of psychological medicine · 2024Review
- A conceptual framework for psychiatric nurses to facilitate medication compliance among adults living with depression.Curationis · 2024Article
- Analysis of Medication Adherence Status and Influencing Factors in Adolescents with Major Depressive Episodes.Actas espanolas de psiquiatria · 2024Article
- Impact of trazodone once-a-day on quality of life and functional recovery in adults with major depressive disorder: A prospective, observational study.Brain and behavior · 2024Observational
- Translation from Preclinical Research to Clinical Trials: Transdermal Drug Delivery for Neurodegenerative and Mental Disorders.Pharmaceutical research · 2024Review
- Adherence to dietary recommendations mediates the effect of affective temperaments on infertility treatment outcomes.Scientific reports · 2024Article
- Conflict-Related Breakdowns in Routine Medical Care - Longitudinal Outcomes for Civilians with Pre-Existing Cognitive Impairment.Aging and disease · 2024Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adherence to antidepressants is crucial for optimal treatment outcomes when treating depressive disorders. However, poor adherence is common among patients prescribed antidepressants. This targeted review summarizes the main factors associated with poor adherence, interventions that promote antidepressant adherence, pharmacological aspects related to antidepressant adherence, and formulates 10 clinical recommendations to optimize antidepressant adherence. Patient-related factors associated with antidepressant non-adherence include younger age, psychiatric and medical comorbidities, cognitive impairment, and substance use disorders. Prescriber behavior-related factors include neglecting medical and family histories, selecting poorly tolerated antidepressants, or complex antidepressant regimens. Multi-disciplinary interventions targeting both patient and prescriber, aimed at improving antidepressant adherence, include psychoeducation and providing the patient with clear behavioral interventions to prevent/minimize poor adherence. Regarding antidepressant choice, agents with individually tailored tolerability profile should be chosen. Ten clinical recommendations include four points focusing on the patient (therapeutic alliance, adequate history taking, measurement of depressive symptoms, and adverse effects improved access to clinical care), three focusing on prescribing practice (psychoeducation, individually tailored antidepressant choice, simplified regimen), two focusing on mental health services (improved access to mental health care, incentivized adherence promotion and monitoring), and one relating to adherence measurement (adherence measurement with scales and/or therapeutic drug monitoring).
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