Evidence map›Paper›PMID 32490900›Full record

ArticleActa cirurgica brasileira2020

Effect of low intensity photobiomodulation associated with norbixin-based poly (hydroxybutyrate) membrane on post-tenotomy tendon repair. In vivo study.

Lízia Daniela E Silva Nascimento, Renata Amadei Nicolau, Antônio Luiz Martins Maia Filho, Kárita Francisca E Silva Nascimento, José Zilton Lima Verde Santos, Rayssilane Cardoso de Sousa, Luiz Fernando Meneses Carvalho, Vicente Galber Freitas Viana

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta cirurgica brasileira, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Lízia Daniela E Silva NascimentoHealth Sciences Center, Universidade do Vale do Paraíba, Teresina, PI, Brazil.ORCID 0000-0001-5837-8311
Renata Amadei NicolauPostgraduate Program in Biomedical Engineering of the Research and Development Institute, Research and Development Institute, UNIVAP, Sao Jose dos Campos, SP, Brazil.ORCID 0000-0002-7687-7963
Antônio Luiz Martins Maia FilhoHealth Sciences Center, Researcher of the Biotechnology and Biodiversity Core, UESPI, Teresina, PI, Brazil.ORCID 0000-0001-6184-8003
Kárita Francisca E Silva NascimentoDepartment of Social Assistance, SASC, Teresina, PI, Brazil.ORCID 0000-0003-2985-6032
José Zilton Lima Verde SantosCenter of Health Sciences, Medicine and Physical Therapy, UESPI, Brazil.ORCID 0000-0001-9877-1994
Rayssilane Cardoso de SousaPostgraduate Program in Biotechnology, Universidade Federal do Piauí, Teresina, PI, Brazil.ORCID 0000-0003-4244-1560
Luiz Fernando Meneses CarvalhoPostgraduate Program in Material Engineering, Federal Institute of Education, Science and Technology of Piaui, Teresina, PI, Brazil.ORCID 0000-0002-1032-0230
Vicente Galber Freitas VianaPostgraduate Program in Material Engineering (PPGEM), IFPI, Teresina, PI, Brazil.ORCID 0000-0002-3863-6974
Universidade do Vale do Paraíba · BRUniversidade Federal do Piauí · BRCentro Universitário UNINOVAFAPI · BRInstituto Federal do Piauí · BRUnifor · NOUniversidade Estadual do Piauí · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the in vivo response of photobiomodulation therapy associated with norbixin-based poly(hydroxybutyrate) membrane (PHB) in tenotomized calcaneal tendon.

methodsThirty rats were randomly allocated to six groups (n=5 each): LED groups (L1, L2 and L3) and membrane + LED groups (ML1, ML2 and ML3). The right calcaneal tendons of all animals were sectioned transversely and were irradiated with LED daily, one hour after surgery every 24 hours, until the day of euthanasia. At the end of the experiments the tendons were removed for histological analysis.

resultsThe histological analysis showed a significant reduction in inflammatory cells in the ML1, ML2 and ML3 groups (p=0.0056, p=0.0018 and p<0.0001, respectively) compared to those in the LED group. There was greater proliferation of fibroblasts in the ML1 (p<0.0001) and L3 (p<0.0001) groups. A higher concentration of type I collagen was also observed in the ML1 group (p=0.0043) replacing type III collagen.

conclusionPhotobiomodulation in association with norbixin-based PHB membrane led to control of the inflammatory process. However, it did not favor fibroblast proliferation and did not optimize type I collagen formation in the expected stage of the repair process.

Indexed as

Achilles TendonAnimalsCarotenoidsCollagenCollagen Type ICollagen Type IIIDrug Evaluation, PreclinicalFibroblastsHydroxybutyratesLow-Level Light TherapyMaleProhibitinsRandom AllocationRatsRats, WistarTendinopathyCarotenoidsCollagenCollagen Type ICollagen Type IIIHydroxybutyratesnorbixinPhb protein, ratProhibitins

Identifiers

PMID32490900
PMCPMC7357841
OpenAlexW3028379786

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.