Evidence map›Paper›PMID 32490711›Full record

ArticleVirulence2020

Bacterial adhesion inhibitor prevents infection in a rodent surgical incision model.

R M Huebinger, D H Do, D L Carlson, X Yao, D H Stones, M De Souza Santos, D P Vaz, E Keen, S E Wolf, J P Minei and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virulence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

R M HuebingerDepartment of Surgery, Division of General and Acute Care Surgery, University of Texas Southwestern Medical Center , Dallas, TX, USA.ORCID 0000-0003-3392-9038
D H DoDepartment of Surgery, Division of General and Acute Care Surgery, University of Texas Southwestern Medical Center , Dallas, TX, USA.ORCID 0000-0002-0904-8727
D L CarlsonDepartment of Surgery, Division of General and Acute Care Surgery, University of Texas Southwestern Medical Center , Dallas, TX, USA.
X YaoDepartment of Surgery, Division of General and Acute Care Surgery, University of Texas Southwestern Medical Center , Dallas, TX, USA.
D H StonesSchool of Biosciences, Institute of Microbiology and Infection, University of Birmingham , Birmingham, UK.
M De Souza SantosDepartment of Molecular Biology, University of Texas Southwestern Medical Center , Dallas, TX, USA.
D P VazDepartment of Microbiology and Molecular Genetics, University of Texas Health Science Center at Houston, McGovern Medical School , Houston, TX, USA.
E KeenSchool of Biosciences, Institute of Microbiology and Infection, University of Birmingham , Birmingham, UK.ORCID 0000-0002-3472-7887
S E WolfDepartment of Surgery, Division of General and Acute Care Surgery, University of Texas Southwestern Medical Center , Dallas, TX, USA.
J P MineiDepartment of Surgery, Division of General and Acute Care Surgery, University of Texas Southwestern Medical Center , Dallas, TX, USA.
K P FrancisPerkin Elmer , Hopkinton, MA, USA.
K OrthDepartment of Molecular Biology, University of Texas Southwestern Medical Center , Dallas, TX, USA.
A M KrachlerDepartment of Microbiology and Molecular Genetics, University of Texas Health Science Center at Houston, McGovern Medical School , Houston, TX, USA.ORCID 0000-0002-0936-0016
The University of Texas Southwestern Medical Center · USThe University of Texas Health Science Center at Houston · USHoward Hughes Medical Institute · USPerkinElmer (United States) · USShriners Hospitals for Children - Galveston · USUniversity of Birmingham · GBUniversity of Gloucestershire · GB

Funding

Mechanoregulation of EHEC virulenceR01AI132354 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Anne-Marie Krachler · 2018 to 2026
$3.5M
Proteostasis, AMPylation and the Unfolded Protein repsonse (UPR)R01GM115188 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI ORTH, KIM · 2015 to 2018
$1.2M
NIAID NIH HHS R01 AI132354NIGMS NIH HHS R01 GM115188
6 · The paper itself

Abstract

Surgical site infection risk continues to increase due to lack of efficacy in current standard of care drugs. New methods to treat or prevent antibiotic-resistant bacterial infections are needed. Multivalent Adhesion Molecules (MAM) are bacterial adhesins required for virulence. We developed a bacterial adhesion inhibitor using recombinant MAM fragment bound to polymer scaffold, mimicking MAM7 display on the bacterial surface. Here, we test MAM7 inhibitor efficacy to prevent Gram-positive and Gram-negative infections. Using a rodent model of surgical infection, incision sites were infected with antibiotic-resistant bioluminescent strains of

Indexed as

AnimalsAnti-Bacterial AgentsBacterial AdhesionBacterial LoadGram-Negative Bacterial InfectionsGram-Positive Bacterial InfectionsMalePseudomonas InfectionsRats, Sprague-DawleySkinStaphylococcal InfectionsSurgical Wound InfectionVirulenceAnti-Bacterial Agentsanti-virulencebacterial adhesionincisionlacerationpseudomonasstaphylococcusSurgical infection

Identifiers

PMID32490711
PMCPMC7550027
OpenAlexW3032622644

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.