ArticleTurkish journal of medical sciences2020
Does capsaicin have therapeutic benefits in human colon adenocarcinoma? Selection of the most reliable dose via AgNOR
Article in Turkish journal of medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Review
- The detection of pomegranate (Toxicology research · 2024Article
- Determination of Rutin's antitumoral effect on EAC solid tumor by AgNOR count and PI3K/AKT/mTOR signaling pathway.Medical oncology (Northwood, London, England) · 2023Article
- The Effects of Capsaicin on Gastrointestinal Cancers.Molecules (Basel, Switzerland) · 2020Review
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/aim: To determine the effect of different doses of capsaicin on AgNOR protein synthesis in human colon adenocarcinoma derivate from colon cancer (Caco-2 cell). Materials and methods: In this experimental study, after the cultured of Caco-2 cell line, the cells are divided into 4 groups as control and different capsaicin exposed doses (25uμ, 50uμ, and 75uμ). Mean AgNOR number and total AgNOR area/nuclear area (TAA/NA) were calculated. Results: A significant differences were detected between control and capsaicin (50uμ) (P = 0.001), between control and capsaicin (75uμ) (P = 0.000), between capsaicin (25uμ) and capsaicin (50uμ) (P = 0.001) and between capsaicin (25uμ) and capsaicin (75uμ) (P = 0.000) for TAA/NA. Also, there were significant differences between control and capsaicin (50uμ) (P = 0.001), between control and capsaicin (75uμ) (P = 0.000), between capsaicin (25uμ) and capsaicin (50uμ) (P = 0.000) and between capsaicin (25uμ) and capsaicin (75uμ) (P = 0.000) for mean AgNOR number. Conclusion: A certain amount of capsaicin has a protective effect against colon adenocarcinoma and the dose concentrations are important for the most reliable treatment.
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