Evidence map›Paper›PMID 32490573›Full record

ArticleThe American journal on addictions2020

Evaluation of a Novel Protocol for Assessment and Treatment of Alcohol Withdrawal Syndrome in Psychiatric Inpatients.

Michael Butterfield, Lucas Thorne-Humphrey, Joji Suzuki, Nicole Herschenhous

Open access · greenAbstract readEvaluation Study
In one paragraph

Article in The American journal on addictions, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Michael ButterfieldDepartment of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.
Lucas Thorne-HumphreyFaculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
Joji SuzukiDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0001-5659-6147
Nicole HerschenhousDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.ORCID 0000-0002-4089-0349
University of British Columbia · CADalhousie University · CAHarvard University · US

Funding

Initiating substance use disorder treatment in hospitalized opioid use disorder patientsK23DA042326 · NIDA · BRIGHAM AND WOMEN'S HOSPITAL · PI SUZUKI, JOJI · 2017 to 2021
$999k
NIDA NIH HHS K23 DA042326NIH k-award K23DA042326
6 · The paper itself

Abstract

BACKGROUND AND

objectivesDespite the high incidence of alcohol withdrawal syndrome (AWS) in psychiatric inpatients, standardized methods for assessing and treating AWS have been studied only once before in this population. We evaluated a novel AWS assessment and treatment protocol designed for psychiatric inpatients.

methodsThis retrospective cohort study evaluated outcomes before and after implementation of the protocol. We collected consecutive data on patients (N = 138) admitted to inpatient psychiatric units at a single center. Participants were patients admitted for nonsubstance-related psychiatric reasons, who were also at risk for developing AWS. Those who developed AWS were treated with either (a) treatment as usual (TAU) or (b) a novel standardized protocol. The primary outcome was duration of benzodiazepine treatment for symptoms of alcohol withdrawal. Secondary outcomes included cumulative benzodiazepine dose administered, treatment duration, and incidence of complications.

resultsOf 138 participants, 83 received TAU and 55 were assessed and treated with the novel protocol. Median duration of benzodiazepine treatment following protocol implementation was 19.7 hours (interquartile range [IQR], 0-46) prior to implementation (TAU) and 0 hours (IQR, 0-15) following protocol implementation (protocol group) (P < .0001). Median benzodiazepine dose (in diazepam equivalents) administered to participants was 30 mg (IQR, 0-65) for TAU and 5 mg (IQR, 0-30) for the protocol group (P < .001). Adverse events before and after implementation occurred in 4.8% and 0%, respectively (P = .15). CONCLUSION AND SCIENTIFIC SIGNIFICANCE: This study provides preliminary evidence for the efficacy and safety of a novel standardized AWS protocol for psychiatric inpatients. This is the first known study assessing an AWS assessment and treatment protocol designed for psychiatric inpatients. (Am J Addict 2020;29:500-507).

Indexed as

Adjustment DisordersAdultAlcohol-Related DisordersAnxiety DisordersBenzodiazepinesBipolar DisorderClinical ProtocolsDiagnosis, Dual (Psychiatry)Dose-Response Relationship, DrugDrug Administration ScheduleFeasibility StudiesFemaleHospitalizationHospitals, PsychiatricHumansHypnotics and SedativesBenzodiazepinesHypnotics and Sedatives

Identifiers

PMID32490573
PMCPMC8290352
OpenAlexW3032621538

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.