Evidence map›Paper›PMID 32490369›Full record

ArticleEClinicalMedicine2020

First successful field evaluation of new, one-minute haemozoin-based malaria diagnostic device.

Rajat Kumar, Anil K Verma, Shweta Shrivas, Priyaleela Thota, Mrigendra P Singh, S Rajasubramaniam, Aparup Das, Praveen K Bharti

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EClinicalMedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 38 citations in OpenAlex.

  1. Trial
  2. Review
  3. Heme oxygenase-1 and malaria pathogenesis.Frontiers in immunology · 2026
    Review
  4. Observational
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. A Lab-On-chip Tool for Rapid, Quantitative, and Stage-selective Diagnosis of Malaria.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Rajat KumarICMR-National Institute of Research in Tribal Health (NIRTH), Jabalpur, Madhya Pradesh, India.
Anil K VermaICMR-National Institute of Research in Tribal Health (NIRTH), Jabalpur, Madhya Pradesh, India.
Shweta ShrivasICMR-National Institute of Research in Tribal Health (NIRTH), Jabalpur, Madhya Pradesh, India.
Priyaleela ThotaHemex Health, Portland, OR, United States of America.
Mrigendra P SinghNational Institute of Malaria Research-Field station (NIMR-FS), Jabalpur, Madhya Pradesh, India.
S RajasubramaniamICMR-National Institute of Research in Tribal Health (NIRTH), Jabalpur, Madhya Pradesh, India.
Aparup DasICMR-National Institute of Research in Tribal Health (NIRTH), Jabalpur, Madhya Pradesh, India.
Praveen K BhartiICMR-National Institute of Research in Tribal Health (NIRTH), Jabalpur, Madhya Pradesh, India.
National Institute for Research in Tribal Health · INNational Institute of Malaria Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEarly and accurate diagnosis of malaria is critical to the success of malaria elimination. However, the current mainstay of malaria diagnosis in the field, such as light microscopy and rapid diagnostic tests (RDTs), have limitations due to low parasite density or mutation in diagnostic markers.

methodsWe evaluated an inexpensive, robust, rapid, malaria diagnostic device, called Gazelle, that employs magneto-optical detection to identify haemozoin crystals (Hz) produced by all species of human malaria parasites in infected individuals. A beam of polarised light is passed through the lysed diluted blood sample under the influence of high (~.55T) and low magnetic fields. The difference in light transmission through the sample between the high and low magnetic fields indicates presence of Hz, suggesting possible malarial infection. A total of 300 febrile patients were screened at the malaria clinic of Indian Council of Medical Research-National Institute of Research in Tribal Health (ICMR-NIRTH), Jabalpur, India, from August 2018 to November 2018. Malaria diagnosis was done using four diagnostic methods: Gazelle, light microscopy, RDT, and malaria specific Polymerase Chain Reaction (PCR). Measures of diagnostic accuracy were compared.

findingsOut of 300 febrile patients enroled and tested for the presence of malaria parasites, 262 patient samples were included in the final analysis. The sensitivity and specificity of Gazelle was 98% and 97% in comparison to light microscopy, 82% and 99% to PCR and 78% and 99% to RDT, respectively. The results of the four diagnostic methods were comparable and statistically no significant differences in sensitivity or specificity was observed between these methods. Enhanced diagnostic accuracy of Gazelle in malaria patients with no prior history of malaria treatment was observed in this study.

interpretationThe diagnostic ability of Gazelle was comparable to light microscopy and better than RDTs even in low parasitemia and in presence of

fundingHemexDx, India.

Indexed as

GazelleHaemozoinMalaria diagnosisP. falciparumRapid diagnostic test

Identifiers

PMID32490369
PMCPMC7256309
OpenAlexW3026363780

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.