ArticleAnnals of gastroenterological surgery2020
Perioperative antithrombotic management of patients who receive direct oral anticoagulants during gastroenterological surgery.
Article in Annals of gastroenterological surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Perioperative management of colorectal surgical patients receiving a direct oral anticoagulant: a scoping review, particular emphasis on procedure-specific risks, and pharmacogenomics.Frontiers in cardiovascular medicine · 2026Review
- Outcomes of Antithrombotic Therapy in Patients Undergoing Gastrointestinal Surgery: A Meta-Analysis.Cureus · 2025Review
- Enhanced management strategy of synchronous percutaneous biopsy and microwave ablation in patients with lung ground-glass opacities undergoing antithrombotic treatment: a clinical perspective on our experience.Frontiers in oncology · 2025Article
- Relationship between antithrombotic drugs and postoperative outcomes in patients with gastric cancer after gastrectomy: a propensity matching analysis.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2023Article
- Review
- Safety of pancreatic surgery with special reference to antithrombotic therapy: A systematic review of the literature.World journal of clinical cases · 2021Article
- Perioperative antithrombotic management of patients who receive direct oral anticoagulants during gastroenterological surgery.Annals of gastroenterological surgery · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimWe investigated the effect of perioperative management of direct oral anticoagulants (DOACs) on bleeding and thromboembolic complications during gastroenterological (GE) surgery.
methodsA total of 334 patients receiving anticoagulants and undergoing elective GE surgery between 2012 and 2018 were enrolled. The patients were divided into three groups: patients receiving warfarin (WF, n = 231), patients receiving DOACs with heparin bridging (DOAC-HB, n = 34), and patients receiving DOAC without heparin bridging (DOAC-NHB, n = 69). Outcome variables were compared between the groups and the risk factors of postoperative bleeding were assessed using logistic multivariate analysis.
resultsNo significant differences were observed in background characteristics between the groups. There were similarities between the groups in surgical blood loss (
conclusionsElective GE surgery can be safely performed in patients receiving DOACs without heparin bridging. Perioperative heparin bridging during DOAC interruption is not recommended even for patients undergoing major GE surgery due to increased postoperative bleeding.
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