Evidence map›Paper›PMID 32490188›Full record

ArticleACS central science2020

Application of Mitochondrially Targeted Nanoconstructs to Neoadjuvant X-ray-Induced Photodynamic Therapy for Rectal Cancer.

Wei Deng, Kelly J McKelvey, Anna Guller, Alexey Fayzullin, Jared M Campbell, Sandhya Clement, Abbas Habibalahi, Zofia Wargocka, Liuen Liang, Chao Shen and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS central science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 91 citations in OpenAlex.

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  8. Mitochondrial Reactive Oxygen Species (mROS) Generation and Cancer:International journal of nanomedicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Wei DengARC Centre of Excellence for Nanoscale Biophotonics, Graduate School of Biomedical Engineering, University of New South Wales, Kensington, New South Wales 2052, Australia.
Kelly J McKelveyBill Walsh Translational Cancer Research Laboratory, The Northern Clinical School, Faculty of Medicine and Health, The University of Sydney and Northern Sydney Local Health District Research (Kolling Institute), St Leonards, New South Wales 2065, Australia.
Anna GullerARC Centre of Excellence for Nanoscale Biophotonics, Graduate School of Biomedical Engineering, University of New South Wales, Kensington, New South Wales 2052, Australia.
Alexey FayzullinARC Centre of Excellence for Nanoscale Biophotonics, Graduate School of Biomedical Engineering, University of New South Wales, Kensington, New South Wales 2052, Australia.
Jared M CampbellARC Centre of Excellence for Nanoscale Biophotonics, Graduate School of Biomedical Engineering, University of New South Wales, Kensington, New South Wales 2052, Australia.
Sandhya ClementARC Centre of Excellence for Nanoscale Biophotonics, Graduate School of Biomedical Engineering, University of New South Wales, Kensington, New South Wales 2052, Australia.
Abbas HabibalahiARC Centre of Excellence for Nanoscale Biophotonics, Graduate School of Biomedical Engineering, University of New South Wales, Kensington, New South Wales 2052, Australia.
Zofia WargockaARC Centre of Excellence for Nanoscale Biophotonics, Graduate School of Biomedical Engineering, University of New South Wales, Kensington, New South Wales 2052, Australia.
Liuen LiangDepartment of Physics and Astronomy, Faculty of Science and Engineering, Macquarie University, North Ryde, New South Wales 2109, Australia.
Chao ShenFaculty of Science and Engineering, Macquarie University, North Ryde, New South Wales 2109, Australia.
Viive Maarika HowellBill Walsh Translational Cancer Research Laboratory, The Northern Clinical School, Faculty of Medicine and Health, The University of Sydney and Northern Sydney Local Health District Research (Kolling Institute), St Leonards, New South Wales 2065, Australia.
Alexander Frank EngelSydney Medical School, University of Sydney, Sydney, New South Wales 2006, Australia.
Ewa M GoldysARC Centre of Excellence for Nanoscale Biophotonics, Graduate School of Biomedical Engineering, University of New South Wales, Kensington, New South Wales 2052, Australia.
UNSW Sydney · AUMacquarie University · AUNorthern Sydney Local Health District · AUSechenov University · RUThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this work, we brought together two existing clinical techniques used in cancer treatment-X-ray radiation and photodynamic therapy (PDT), whose combination termed X-PDT uniquely allows PDT to be therapeutically effective in deep tissue. To this end, we developed mitochondrially targeted biodegradable polymer poly(lactic-

Identifiers

PMID32490188
PMCPMC7256935
OpenAlexW3018552677

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.